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Diss Factsheets
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EC number: 210-959-9 | CAS number: 626-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific standards with restrictions due to the limited documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- BASF test
Aqueous preparations of the test substance were injected into the peritoneal cavity of the mice. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpiperidine
- EC Number:
- 210-959-9
- EC Name:
- 1-methylpiperidine
- Cas Number:
- 626-67-5
- Molecular formula:
- C6H13N
- IUPAC Name:
- 1-methylpiperidine
- Details on test material:
- - Name of test material (as cited in study report): Methylpiperidine
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean body weight at study initiation: 33.7 ± 2.86 g (males), 29.4 ± 2.99 g (females)
ENVIRONMENTAL CONDITIONS
no details given
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- VEHICLE
- Concentration in vehicle: The doses were applied as 0.5 % (50 µL/kg bw), 1 % (100 µL/kg bw), 2 % (125, 160 and 200 µL/kg) , or 20 % (1600 µL/kg bw) v/v preparations of the test substance in aqua dest.
- Justification for choice of vehicle: soluble in water
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg - Doses:
- 50, 100, 125, 160, 200, and 1600 µL/kg bw (corresponding to approx. 41, 82, 102, 131, 163 and 1306 mg/kg bw; calculation based on density of 0.8165 g/cm³)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 13 days
- Frequency of observations and weighing: Cageside observations were performed several times on the day of administration and daily on workdays during observation period. Body weights were determined at test start for dose determination.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, gross-pathological investigation
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 94 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponding to 115 µL/kg bw; calculation was based on a density of 0.8165 g/cm³
- Mortality:
- 1306 mg/kg bw: 5/5 males and females died within 15 min after administration;
163 mg/kg bw: males: 4/5 animals died within 24 hours; females: 1/5 animals died within 1 hour, 4/5 within 7 days and 5/5 within 14 days after administration;
131 mg/kg bw: males: 2/5 males died within 24 hours, 4/5 within 48 hours and 5/5 within 7 days; females: 3/5 animals died within 24 hours; 5/5 within 7 days;
102 mg/kg bw: males: 3/5 animals died within 48 hours; females: 4/5 animals died within 7 days and 5/5 within 14 days.
82 and 41 mg/kg bw: 0/5 males and 0/5 females died, respectively - Clinical signs:
- 1306 mg/kg bw: immediately after application of the test substance sedate behaviour, accelerated respiration, sunken flanks.
41 to 163 mg/kg bw: immediately after injection, high stepping gait, sunken flanks, sedate behaviour, accelerated respiration, spasmodic convulsions. Ca. 4 hours after treatment sedate behaviour, partly abdominal position, irregular accelerated respiration, closed eyes, scrubby fur, crouched position. From day 7 no abnormalities were detectable in surviving animals.
172 to 34 mg/kg bw: after treatment intermittent respiration, abdominal position and apathy. On day 2 moderate food intake and scrubby fur. On day 2 adhering eye lids and poor general state until death.
27 to 21 mg/kg bw: after treatment slightly accelerated respiration, moderate food intake. On day one no abnormalities detectable.
- Body weight:
- No data
- Gross pathology:
- Deceased animals: putrefaction in all animals, three times adhesions between liver and stomach, 5 times intraabdominal adhesion compared to putrefaction.
Sacrifized animals: three times adhesions at the liver region, twice conjunctive tissue adhesions between intestinal loops, substance incorporation between liver and stomach. Otherwise, no abnormalities detected in organs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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