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Diss Factsheets
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EC number: 448-300-4 | CAS number: 88642-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: activated sludge form the sewage treatment plant in Schmallenberg, Germany. Mainly fed with municipal wastewater.
- Preparation of inoculum for exposure: The samples were washed once with mineral medium after the arrival at the laboratory and kept aerobic until use
- Concentration of sludge: 28.3 mg dry weight/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Initial conc.:
- 3.05 other: mg O2/ mg test item
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22 °C
- pH: 7.8 -8.4
TEST SYSTEM
- Culturing apparatus: Sapromat respirometer
- Number of culture flasks/concentration:
- Test vessel: 2 replicates
- Inoculum blank: 2 replicates
- Abiotic contzrol: 2 replicates
- Procedural control: 2 replicates
- Toxicity control: 2 replicates - Reference substance:
- other: sodium benzoate
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 80
- Sampling time:
- 28 d
- Details on results:
- Mean degradation kinetic (test substance):
12 % degradation after 3 d
44 % degradation after 7 d
54 % degradation after 10 d
60 % degradation after 12 d
72 % degradation after 20 d
76 % degradation after 24 d
80 % degradation after 28 d
Mean degradation kinetic (toxicity control):
14 % degradation after 1 day
30 % degradation after 7 days
40 % degradation after 14 days
56 % degradation after 28 days
Validation criteria:
- The differente of extremes of replicate values of the removal of the test item at the end of the test and at the end of the 10-d window is less than 20%,
- The percentage degradation of the reference item has reached the pass level of 60% by day 14,
- The oxygen uptake of the inoculum blank is < 60 mg/I in 28 days and the pH value is within the range 6.0 - 8.5. - Results with reference substance:
- Degradation kinetic:
33 % degradation after 1 d
82 % degradation after 14 d
89 % degradation after 28 d - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Due to an biodegradation over 60 % within the 10-day-window, the test item can be identified as readily biodegradable.
Reference
Description of key information
Readily biodegradable: 80% biodegradation after 28 d (OECD 301 F)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
One experimental study is available investigating the ready biodegradability of the test substance. The study was performed according to OECD Guideline 301 F and GLP. Non-adapted activated sludge from a domestic sewage treatment plant was used as inoculum. After 28 days 80% degradation of the test substance was recorded based on O2-consumption. The 10-day window was met. Thus, the test substance is readily biodegradable according to the OECD criteria. A toxicity control containing both, reference substance and test substance did not indicate inhibitory effects to the inoculum (40% degradation after 14 d). All validity criteria were met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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