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EC number: 218-080-2 | CAS number: 2050-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- The Pentyl salicylate is found in a high proportion in the Reaction mass of 2-methylbutyl salicylate and pentyl salicylate registered by Givaudan, hence the structural similarities are elevated.
- Reason / purpose for cross-reference:
- read-across source
- Specific details on test material used for the study:
- -Commercial name: Amyl Salicylate
-Chemical nature: Mixture of Pentyl 2-hydroxybenzoate and 3-Methylbutyl 2-hydroxybenzoate
-Givaudan Code No: 8810001
- Physical state: Liquid
- Analytical purity: 98.8% (sum of two isomers) 66.6% Pentyl 2-hydroxybenzoate; 32.2% 3-Methylbutyl 2-hydroxybenzoate
- Lot/batch No.: VE00100713
- Expiration date: September 10, 2011 - Details on study design: HPLC method:
- Equipment and procedures:
HPLC equipment: Perkin Elmer (series 200) HPLC system comprising:
- a high pressure pump (module N2910102, serial number: 291N8051901A)
- an autosampler (module N2930100, serial number: 293N8052404A)
- a column compartment (module N2601581, serial number: OVH0802151130)
- a variable wavelength detector (module N2920010, serial number: 292N8050804E)
- Column: 250 mm x 4.6 mm i.d., Nucelodur® 100-5 CN-RP (Macherey-Nagel) serial number: N8030929, batch 3034
- Mobile phase: methanol/water 55/45 (v/v))
- Flow rate: 1.0 ml/min
- Column temperature: 35°C
- detection wavelength: 210 nm
- Injected volume: 100µl
Reference substances:
Six substances were chosen having log Koc ranging from 1.45 to 5.63. Formamide is used as an unretained compound for the determination of the dead time t0.
Individual solutions of these seven substances in methanol were prepared at the concentrations given in Table 1.
HPLC procedure:
A solution of the test substance was prepared 10.0 mg in 20 ml methanol/water 55/45 v/v).
After equilibration of the HPLC system, the calibration mixture was injected first, followed by the test chemical solution twicw and the calibration mixture again.
Retention times tR were measured and averaged and the decimal logarithms of the capacity factors k were calculated. The linear regression parameters of the relationship
Log Koc = f(log k)
Were also calculated from the data obtained with the calibration mixture and, therewith, log Koc of the test substance was determined from its measured capacity factor.
Finally solutions of the reference substances were injected individually to confirm the peak assignment. - Type:
- log Koc
- Value:
- 3.7 dimensionless
- Details on results (HPLC method):
- The chromatograms of Amyl Salicylate show two partially resolved peaks at average retention times of 8.60 and 8.83 minutes. Both retention times correspond to adsorption coefficients (log value) of 3.7.
Detailed results are given in Appendix 1 and illustrated by the graph in Appendix 2. - Conclusions:
- The adsorption coefficient (Koc) of Amyl Salicylate was log Koc = 3.7
Reference
Description of key information
The Adsorption coefficient (Koc) on soil and on sewage sludge of Amyl Salicylate was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to OECD Guideline 121. The log Koc was 3.7, equivalent to a Koc of 5012.
Key value for chemical safety assessment
- Koc at 20 °C:
- 5 012
Additional information
The chromatograms of Amyl Salicylate show two partially resolved peaks at average retention times of 8.60 and 8.83 minutes. Both retention times correspond to adsorption coefficients (log value) of 3.7.
[LogKoc: 3.7]
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