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Diss Factsheets
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EC number: 206-420-2 | CAS number: 338-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Perfluorotripropyl amines (PTPA) is not expected to be toxic to fish at the limit of solubility (5.96 µg/L) by readacross from category members. When other category members were tested, no toxicity was observed to fish in tests conducted with nominal concentrations ranging from 100 to 2700 mg/L . This categorical result is considered applicable to PTPA.
Key value for chemical safety assessment
Additional information
Perfluorotripropyl amines (PTPA) is a member of the Perfluorinated Organic Chemicals, C5-C18 category. Because these substances exhibit similarity in their physicochemical properties and toxicological properties in mammals, and because available data indicates that parent molecules are not reactive toward biological molecules and cannot undergo bioactivation by normal enzymatic processes, they can be considered members of a chemical category. Data gaps for ecological toxicity can therefore be addressed by read-across and/or trend analysis between category members. Short-term toxicity of PTPA to fish has not been studied. However, two reliable studies are available for other category members. Perfluoro-N-C1,3-alkyl morpholines (FC-770) was tested using D. rerio. After 96-hours, no toxicity was observed from a water-soluble fraction prepared at 100 mg/L. The mean measured concentration during the test was 0.096 mg/L. Perfluoro-C6,8-furans, pyrans and acyclic ethers (FC-77) was tested using P. promelas. In this case, test chambers were prepared at an initial loading rate of 1000 mg/L. Exposure concentrations were not measured, however, the test material could not be entirely dissolved and was observed in the test chambers throughout the experiment. No toxicity was observed. Other category members had study reports which were less detailed but were suitable for weight of evidence in the aggregate. These category members were not toxic to fish in limit tests with nominal concentrations ranging from 750 to 2700 mg/L. The analytically determined concentrations for FC-770 is are not reasonable to use for readacross since FC-770 solubility is substantially higher than that of PTPA. Lack of toxicity at the limit of solubility is read across qualitatively to PTPA. The solubility of PTPA was determined to be 5.96 µg/L in organism-free Daphnia medium controls during the short-term toxicity test. This value is greater than the measured PTPA solubility in water (0.381 µg/L) but less than the analytically determined concentrations in medium containing live daphnids. The organism-free medium solubility value is understood to be better representative of PTPA solubility in natural waters, and avoids potential impacts on the analytical result by the action of living organisms. Therefore, 5.96 µg/L is accepted as the basis for estimating the highest possible exposure concentration of PTPA in order to define the LC50.
Please see IUCLID section 13 for the category justification and a matrix of aquatic toxicity data for members of the Perfluorinated Organic Chemicals C5-C18 category.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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