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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest 72h-EC50 of >100 mg/L (for dipropylene glycol), it can be assumed that the 72h-EC50 for ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.00 which indicate a 72h-EC50 value in the range 3000-4000mg/L based on modelling of the components and their likely composition
Key value for chemical safety assessment
Additional information
Monopropylene glycol:
Experimental data are available with fresh water and marine algae. In fresh water, the 96-h EC50 is 19,000 mg/l in Pseudokirchnerella subcapitata (reported as Selenastrum capricornutum) and the 14-d NOEC is 15,000 mg/l (ARCO Chemical Company, 1990). In marine water, the 96-h EC50 is 19,100 mg/l in Skeletonema costatum and the 14-d NOEC is <5300 mg/l (ARCO Chemical Company, 1990). The 14-day NOEC values cannot be used, since a NOEC should be a minimum value and the algae are not in the exponential growth phase anymore after 96 hours.
Dipropylene glycol:
A GLP compliant, OECD 201 guideline study is available for dipropylene glycol, measuring a 72-h EC50 and a 72-h NOEC value of >100 mg/l in the green algae Desmodesmus subspicatus (BASF, 2002).
Tripropylene glycol:
One non-GLP compliant guideline study (OECD 201) is available for tripropylene glycol. The 72-h EbC50 value and 72-h NOEbC value is >1,000 mg/l (nominal concentration) inPseudokirchnerella subcapitata(reported as Selenastrum capricornutum) (OECD, 1994). These values are used in the assessment.
QSAR:
A 96-h EC50 = 3000 -4000 mg/l was calculated using ECOSAR v1.11 based on modelling of the individual components.
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