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EC number: 238-034-5 | CAS number: 14177-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Jun 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ICCVAM recommended HET-CAM test method protocol (Nov. 2006)
- Principles of method if other than guideline:
- The in vitro study was performed to evaluate the irritating potential of molybdenum nickel tetraoxide by detection of damages in blood vessels under the chorioallantoic membrane of 9 day incubated chicken eggs.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Straße 7, 55116 Mainz, Germany
Test material
- Reference substance name:
- Molybdenum nickel tetraoxide
- EC Number:
- 238-034-5
- EC Name:
- Molybdenum nickel tetraoxide
- Cas Number:
- 14177-55-0
- Molecular formula:
- MoO3*nNiO (with n in a range of 0.6 - 1)
- IUPAC Name:
- Reaction mass of molybdenum oxide and nickel oxide
- Reference substance name:
- 238-034-0
- IUPAC Name:
- 238-034-0
- Details on test material:
- - Name of test material (as cited in study report): Molybdenum nickel tetraoxide
- Molecular formula: NiMoO4
- Physical state /appearance: light yellow powder
- Analytical purity: >99%
- Lot/batch No.: GRA20100315
- Expiration date of the lot/batch: Feb 2012
- Storage condition: room temperature 20 +/- 5°C; closed vessel
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- other: Lohmann selected Leghorn chicken's eggs
- Strain:
- other: Lohmann selected Leghorn chicken's eggs
- Details on test animals or tissues and environmental conditions:
- The eggs were obtained from LSL Rhein Main Geflügelvermehrungsbetrieb, Dieburg, Germany.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 300 µL (mean weight: 0.1429 g) - Duration of treatment / exposure:
- not applicable; see "any other information on materials and methods"
- Observation period (in vivo):
- not applicable; see "any other information on materials and methods"
- Number of animals or in vitro replicates:
- not applicable; see "any other information on materials and methods" 15 eggs (3 for negative control, 6 for 2 different positive controls, 6 for the test item)
Results and discussion
Any other information on results incl. tables
Table 1: Observations and calculated Irritation Score - Evaluation of Molybdenum nickel tetraoxide in the HET-CAM Test
Test Group |
Amount applied |
Time until Haemorrhage |
Time until Lysis |
Time until Coagulation |
Mean Irritation Score |
|
|
seconds |
seconds |
seconds |
|
Negative Control |
300 µL |
301 |
301 |
301 |
0.00 |
300 µL |
301 |
301 |
301 |
||
300 µL |
301 |
301 |
301 |
||
Positive Control 0.1-N NaOH |
300 µL |
9 |
22 |
15 |
20.02 |
300 µL |
7 |
20 |
13 |
||
300 µL |
7 |
21 |
15 |
||
Positive Control 1% SDS |
300 µL |
14 |
26 |
301 |
11.15 |
300 µL |
16 |
29 |
301 |
||
300 µL |
16 |
27 |
301 |
||
Molybdenum nickel tetraoxide |
0.1659 g |
301 |
301 |
301 |
0.00 |
0.1346 g |
301 |
301 |
301 |
||
0.1364 g |
301 |
301 |
301 |
||
0.1345 g |
301 |
301 |
301 |
||
0.1418 g |
301 |
301 |
301 |
||
0.1441 g |
301 |
301 |
301 |
In the negative control, no signs of irritation were observed.
Both positive controls showed severe irritation.
The test item Molybdenum nickel tetraoxide showed no irritation.
In conclusion, it can be stated that in this study and under the experimental conditions reported, the test item Molybdenum nickel tetraoxide possesses no irritation potential.
Table 2: Classification of the irritation potential
Irritation Score (IS) |
Classification |
0 - 0.9 |
not irritant |
1 - 4.9 |
slightly irritant |
5 - 8.9 |
moderately irritant |
9 - 21 |
severely irritant |
Table 3: Validity criteria and findings
Parameter |
Criterion |
Found |
Assessment |
IS of negative controls |
< 0.9 |
0.0 |
ok |
IS of positive controls |
> 9 |
20.02 (NaOH) |
ok |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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