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EC number: 236-031-3 | CAS number: 13106-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
- Density
- Particle size distribution (Granulometry)
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
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- Endpoint summary
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
A single semi-occlusive application of Ammonium Molybdate to intact rabbit skin for four hours elicited no dermal irritation.
The overall irritation index after 4 days of observation was 0.0.
Hence, Ammonium molybdate can be considered not irritating to skin.
Eye Irritation:
Instillation of Ammonium molybdate into the rabbit eyes elicited transient and very slight conjunctival inflammation only which were completely resolved after 4 days
The overall irritation scores after 7 days was 0.0
Based on the observations and scores, Ammonium molybdate can be considered not irritating to rabbit eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from NTRL reports
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The dermal irritation potential of Ammonium molybdate was assessed in rabbits according to OECD 404 Guidelines
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Sex: Female
- Source: A. Smith, Warlingham. Surrey
- Age at study initiation: 9 to 12 weeks of age
- Weight at study initiation: 2.2 to 2.7 kg
- Fasting period before study:
- Housing: The rabbits were individually housed in metal cages with perforated floors in Building
- Diet (e.g. ad libitum): SDS Standard Rabbit Diet
- Water (e.g. ad libitum):Tap water
- Acclimation period: The rabbits selected for the study were all acclimated to the laboratory environment
ENVIRONMENTAL CONDITIONS
- Temperature (°C):19 deg C
- Humidity (%):Relative humidity:30-70%
- Air changes (per hr): 19 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours of artificial light in each 24 hour period. - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 gm
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Day 1(approximately 30 minutes after removal of the patches) and on Days 2, 3 and 4.
- Number of animals:
- 6 female rabbits
- Details on study design:
- TEST SITE
- Area of exposure: dorso-lumbar region
- % coverage: 10 cm square patch
- Type of wrap if used: Elastoplast
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and the treatment site was washed using water to remove any residual test substance.
SCORING SYSTEM:
Grading and scoring of the dermal reactions were performed using the prescribed numerical scoring system. - Other effects / acceptance of results:
- no data available
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No dermal irritation observed
- Interpretation of results:
- other: not irritating
- Conclusions:
- A single semi-occlusive application of Ammonium Molybdate to intact rabbit skin for four hours elicited no dermal irritation.
The overall irritation index after 4 days of observation was 0.0.
Hence, Ammonium molybdate can be considered not irritating to skin. - Executive summary:
A study was conducted to assess the irritation potential of ammonium molybdate. The study was conducted as per OECD 404 Guidelines.
0.5 gm of test chemical was applied to the dorso-lumbar region exposing an area of skin approximately 10 cm square under 2.5 cm square gauze pad moistened with 0.5 ml distilled water to one intact skin site of 6 female New Zealand White rabbits.Each treatment site was occluded with Elastoplast elastic adhesive dressing for a four hour period.At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and washed and animal were scored in accordance with edema erythema formation.Examination of the treated skin was made on Day 1 (i.e. approximately 30 minutes after removal of the patches) andon Days 2, 3 and 4.There was no response to treatment in any animal throughout the observation period.A single semi-occlusive application of Ammonium Molybdate to intact
rabbit skin for four hours elicited no dermal irritation.
The overall irritation index after 4 days of observation was 0.0.Hence, Ammonium molybdate can be considered not irritating to skin.
Reference
Table: Dermal reactions elicited by Ammonium Molybdate
Rabbit number |
Sex
|
E =Erythema o =Oedema |
Day |
|||
1* |
2 |
3 |
4 |
|||
1 |
female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
2 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
3 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
4 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
5 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
6 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
*-Approximately 30 minutes after removal of dressing
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from NTRL reports
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- The ocular irritation potential of Ammonium molybdate was assessed in rabbits
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Sex: Male
- Source: A. Smith, Warlingham. Surrey
- Age at study initiation: 12 to 13 week
- Weight at study initiation: 2.8 to 3.1 kg
- Fasting period before study:
- Housing: The rabbits were individually housed in metal cages with perforated floors in Building
- Diet (e.g. ad libitum): SDS Standard Rabbit Diet
- Water (e.g. ad libitum):Tap water
- Acclimation period: The rabbits selected for the study were all acclimated to the laboratory environment
ENVIRONMENTAL CONDITIONS
- Temperature (°C):19 deg C
- Humidity (%):Relative humidity:30-70%
- Air changes (per hr): 19 air changes
per hour
- Photoperiod (hrs dark / hrs light): 12 hours of artificial light in each 24 hour period. - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- A 100 mg amount of Ammonium molybdate, the weight occupying a volume of 0.1 ml, was placed into the lower everted lid.
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- Examination of the eyes was made after 1 hour and 1, 2, 3, 4 and.7 days after instillation.
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 6 male rabbits
- Details on study design:
- TEST SITE
- Area of exposure: lower everted lid.
SCORING SYSTEM: Grading and scoring of the ocular lesions were performed according to cornea,iris, Conjunctivae ,chemosis and redness in the eye of rabbit
Grading Scale for Eye Irritation:
Cornea Grade
Opacity: degree of density (readings should be taken from most dense area)*
No ulceration or opacity = 0
Scattered or diffuse areas of opacity (other than slight dulling of normal lustre); details of iris slightly obscured = 1*
Easily discernible translucent area; details of iris slightly obscured = 2*
Opalescent area; no details of iris visible; size of pupil barely discernible = 3*
Opaque cornea; iris not discernible through the opacity = 4*
Area of Cornea Involved
One quarter(or less) but not zero = 1
Greater than one quarter, but less than half = 2
Greater than half, but less than three quarters = 3
Greater than three quarters, up to whole area = 4
Iris
Normal = 0
Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia; or injection; iris reactive to light (a sluggish reaction is considered to be an effect = 1 *
Hemorrhage, gross destruction, or no reaction to light = 2*
Conjunctivae
Redness (refers to palpebral and bulbar conjunctivae; excluding cornea and iris)
Vessels Normal = 0
Some blood vessels definitely hyperaemic (injected) = 1
Diffuse, crimson colour; individual vessels not easily discernible = 2*
Diffuse beefy red = 3 *
Chemosis
Swelling (refers to lids and/or nictating membranes)
No swelling = 0
Any swelling above normal (includes nictating membrane)= 1*
Obvious swelling, with partial eversion of lids = 2*
Swelling, with lids about half closed = 3*
Swelling, with lids more than half closed= 4*
*-interpreted as a positive effect (TSCA test criteria) - Other effects / acceptance of results:
- no data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 days
- Score:
- 0
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- All conjunctival reactions had resolved one to four days after instillation. No corneal or iridial inflammation was seen throughout the observation period . A diffuse crimson-red colouration of the conjunctivae was evident twenty-four hours after instillation only in one animal. Mild conjunctival inflammation was observed in the remaininq animals.
- Interpretation of results:
- other: not irritating
- Conclusions:
- Instillation of Ammonium molybdate into the rabbit eyes elicited transient and very slight conjunctival inflammation only which were completely resolved after 4 days
The overall irritation scores after 7 days was 0.0
Based on the observations and scores, Ammonium molybdate can be considered not irritating to rabbit eyes. - Executive summary:
The ocular irritation potential of Ammonium molybdate was assessed in rabbits. The study was performed according to OECD 405 Guidelines. 100 mg of 0.1 ml chemical was installed into thelower everted lid of 6 New Zealand White male rabbits. The contralateral eye remained untreated and served as a control. Examination of the eyes was made after 1 hour and 1, 2, 3, 4 and.7 days after instillation. Observation of the eyes was aided by the use of a handheld torch. Grading and scoring of the ocular lesions were performed.
One of the animals gave a "positive" response. No corneal damage or iridial inflammation was seen throughout the observation period. A diffuse crimson-red colouration of the conjunctivae was evident twenty-four hours after instillation only in one animal. Mild conjunctival inflammation was observed in the remaininq animals. All conjunctival reactions had resolved one to four days after instillation.
Instillation of Ammonium molybdate into the rabbit eyes elicited transient and very slight conjunctival inflammation only which were completely resolved after 4 days
The overall irritation scores after 7 days was 0.0
Based on the observations and scores, Ammonium molybdate can be considered not irritating to rabbit eyes.
Reference
Ocular reactions elicited by Ammonium molybdate:
Rabbit no. |
Region of eye |
1 hr |
Days after installation |
|||||
1 |
2 |
3 |
4 |
7 |
||||
1 |
Cornea |
Density |
0 |
0 |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
0 |
0 |
||
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
2 |
1 |
1 |
0 |
0 |
|
Chemosis |
1 |
1 |
0 |
0 |
0 |
0 |
||
2 |
Cornea |
Density |
0 |
0 |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
0 |
0 |
||
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
1 |
1 |
1 |
0 |
0 |
|
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
||
3 |
Cornea |
Density |
0 |
0 |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
0 |
0 |
||
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
1 |
1 |
0 |
0 |
0 |
|
Chemosis |
1 |
1 |
0 |
0 |
0 |
0 |
||
4 |
Cornea |
Density |
0 |
0 |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
0 |
0 |
||
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
1 |
0 |
0 |
0 |
0 |
|
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
||
5 |
Cornea |
Density |
0 |
0 |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
0 |
0 |
||
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
0 |
0 |
0 |
0 |
0 |
|
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
||
6 |
Cornea |
Density |
0 |
0 |
0 |
0 |
0 |
0 |
Area |
0 |
0 |
0 |
0 |
0 |
0 |
||
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
0 |
0 |
0 |
0 |
0 |
|
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation:
In different studies,Ammonium molybdate has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical and for the read across substance, sodium molybdate [CAS: 7631-95-0].
A study was conducted (NTRL submission report -OTS0000811, last updated 1991)to assess the irritation potential of ammonium molybdate. The study was conducted as per OECD 404 Guidelines.
0.5 gm of test chemical was applied to the dorso-lumbar region exposing an area of skin approximately 10 cm square under 2.5 cm square gauze pad moistened with 0.5 ml distilled water to one intact skin site of 6 female New Zealand White rabbits.Each treatment site was occluded with Elastoplast elastic adhesive dressing for a four hour period.At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and washed and animal were scored in accordance with edema erythema formation.Examination of the treated skin was made on Day 1 (i.e. approximately 30 minutes after removal of the patches) andon Days 2, 3 and 4.There was no response to treatment in any animal throughout the observation period.A single semi-occlusive application of Ammonium Molybdate to intact rabbit skin for four hours elicited no dermal irritation.
The overall irritation index after 4 days of observation was 0.0.Hence, Ammonium molybdate can be considered not irritating to skin.
This result is supported by the experimental study summarized in NTRL submission report -OTS0000811, last updated 1991; for the read across substance,sodium molybdate [CAS: 7631-95-0].The study was conducted as per OECD 404 Guidelines.
0.5 gm of test chemical was applied to the dorso-lumbar region exposing an area of skin approximately 10 cm square under 2.5 cm square gauze pad moistened with 0.5 ml distilled water to one intact skin site of 6 female New Zealand White rabbits.Each treatment site was occluded with Elastoplast elastic adhesive dressing for a four hour period.At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and washed and animal were scored in accordance with edema erythema formation.Examination of the treated skin was made on Day 1 (i.e. approximately 30 minutes after removal of the patches) andon Days 2, 3 and 4.There was no response to treatment in any animal throughout the observation period.A single semi-occlusive application of sodium Molybdate to intact rabbit skin for four hours elicited no dermal irritation.
The overall irritation index after 4 days of observation was 0.0.Hence, sodium molybdate can be considered not irritating to skin.
Based on the available data for the target and read across substances and applying the weight of evidence approach, ammonium molybdate can be considered as not irritating to skin.Comparing the above annotations with the criteria of CLP regulation, test chemical can be classified under the category “Not Classified”.
Eye Irritation:
In different studies,Ammonium molybdatehas been investigated for potential for ocular irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical and for the read across substance, sodium molybdate [CAS: 7631-95-0].
A study was conducted (NTRL submission report -OTS0000811, last updated 1991)to assess the irritation potential of ammonium molybdate. The study was performed according to OECD 405 Guidelines. 100 mg of 0.1 ml chemical was installed into thelower everted lid of 6 New Zealand White male rabbits. The contralateral eye remained untreated and served as a control. Examination of the eyes was made after 1 hour and 1, 2, 3, 4 and.7 days after instillation. Observation of the eyes was aided by the use of a handheld torch. Grading and scoring of the ocular lesions were performed. One of the animals gave a "positive" response. No corneal damage or iridial inflammation was seen throughout the observation period. A diffuse crimson-red colouration of the conjunctivae was evident twenty-four hours after instillation only in one animal. Mild conjunctival inflammation was observed in the remaininq animals. All conjunctival reactions had resolved one to four days after instillation.
Instillation of Ammonium molybdate into the rabbit eyes elicited transient and very slight conjunctival inflammation only which were completely resolved after 4 days
The overall irritation scores after 7 days was 0.0
Based on the observations and scores, Ammonium molybdate can be considered not irritating to rabbit eyes.
This result is supported by the experimental study summarized in NTRL submission report -OTS0000811, last updated 1991; for the read across substance,sodium molybdate [CAS: 7631-95-0].The study was conducted as per OECD 405 Guidelines. 100 mg of 0.1 ml chemical was installed into thelower everted lid of 6 New Zealand White male and female rabbits. The contralateral eye remained untreated and served as a control. Examination of the eyes was made after 1 hour and 1, 2, 3, 4 and.7 days after instillation. Observation of the eyes was aided by the use of a handheld torch. Grading and scoring of the ocular lesions were performed.
One of the animals gave a "positive" response. No corneal damage or iridial inflammation was seen throughout the
observation period. A diffuse crimson-red colouration of the conjunctivae was evident twenty-four hours after instillation only in one animal. Mild conjunctival inflammation was observed in the remaininq animals. All conjunctival reactions had resolved one to four days after instillation.
Instillation of Sodium molybdate into the rabbit eyes elicited transient and very slight conjunctival inflammation only which were completely resolved after 4 days
The overall irritation scores after 7 days was 0.0
Based on the observations and scores, Sodium molybdate can be considered not irritating to rabbit eyes.
Based on the available data for the target and read across substances and applying the weight of evidence approach, ammonium molybdate can be considered as not irritating to eyes.Comparing the above annotations with the criteria of CLP regulation, test chemical can be classified under the category “Not Classified”
Justification for classification or non-classification
Available studies for ammonium molybdate suggests that it is not irritating to eyes and skin.
Hence,Ammonium molybdate can be classified under the category “Not Classified” as per CLP regulation.
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