Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-958-7 | CAS number: 1461-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No purity or GLP data, but methods well documented.
Data source
Reference
- Reference Type:
- publication
- Title:
- Triphenyltin and tributyltin, single and in combination, promote imposex in the gastropod bolinus brandaris.
- Author:
- Machado Santos et al
- Year:
- 2 006
- Bibliographic source:
- Ecotoxicology and environmental safety, 64: 155-162
Materials and methods
- Type of study / information:
- Endocrine disruption.
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation into the effects on the penis of male and female snails when dosed with the test material
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tributyltin chloride
- EC Number:
- 215-958-7
- EC Name:
- Tributyltin chloride
- Cas Number:
- 1461-22-9
- Molecular formula:
- C12H27ClSn
- IUPAC Name:
- tributylstannanylium chloride
Constituent 1
Results and discussion
Any other information on results incl. tables
Table 1 shows the biological parameters and maturity stages of all the animals used in the experiment. At the end of the experiment, the percentages of mature females were lower in all organotin treatments (43-47 %) versus controls (67 %), indicating a possible interference of organotins with female sexual maturation, as they all came from the same field site and were simultaneously collected.
Table 2 indicates male and female penis size at the beginning of the experiment (T = 0), at 11 days (T = 11), and at 1 month afterward (T = 31) for the organotin-injected animals.
No significant increase (P> 0.05) in male penis size was recorded in any situation after a single injection of the tested organotin compounds relative to the control. However, female penises in the test material (P<0.05) treatments were significantly increased after 31 days. Of all treatments, the mixture of both compounds displayed the highest increase in female's penis length, which by day 31 was significantly different from control or test material-injected females. In addition to increase in female penis size, imposex induction was also observed after test material injection, as a few females (three in the control, two for the test material) had no penis and/or vas deference at the beginning of the experiment, and imposex could be observed at the conclusion of the experiment in all test material-injected females but not in the controls. As at the initiation of the experiment most females were already in imposex stage 4, with a tiny penis in comparison to males, to monitor any changes in the vas deferens sequence index was not possible, and therefore only imposex induction and increase in female penis length were considered in the present study.
Applicant's summary and conclusion
- Conclusions:
- At the end of 4 weeks, significant increases in the female penis size of those gastropods injected with the test material (P <0.05) were recorded.
- Executive summary:
Specimens of Bolinus brandaris (neogastropod) were injected with a single dose of 500 ng/g body weight (b.w.) of test material for a period of up to 31 days. At the end of 4 weeks, significant increases in the female penis size of those gastropods injected with the test material (P <0.05) were recorded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)