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Diss Factsheets
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EC number: 430-910-7 | CAS number: 13335-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 28 - September 11, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterize
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- and 21 CFR 28
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- -
- EC Number:
- 430-910-7
- EC Name:
- -
- Cas Number:
- 13335-71-2
- Molecular formula:
- Hill formula: C10H12O3 CAS formula: C10H12O3
- IUPAC Name:
- 2-(2,6-dimethylphenoxy)acetic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hsd: SPRAGUE DAWLEY®SD®
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley Inc, Indianapolis, Indiana
- Age at study initiation: 7 - 9 weeks
- Weight at study initiation: 200 to 224g
- Fasting period before study: overnight.
- Housing: individually in hanging stainless steel cage
- Diet: Certified Rodent Chow ad libitum
- Water: tap water ad libitum
- Acclimation period: 6 days before
ENVIRONMENTAL CONDITIONS
- Temperature: 69 - 72°F
- Humidity : Ambient
- Photoperiod :12hrs light/12rhs dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.2% hydroxypropyl methylcellulose (HPMC)
- Details on oral exposure:
- dose levels: 0, 125, 250, 500, or 2000 mg/kg. In addition 5 male rats were administered 375 or 437.5 mg/kg
dose volume: 10 ml/kg - Doses:
- 5 males and 5 females were orally administered Abbott -172245 in 0.2% HPMV one time only in doses of 125, 250, 500 or 2,000 mg/kg. In addition 5 male rats were administered doses of 375 or 437.5 mg/kg.
- No. of animals per sex per dose:
- 5 females/males per dose
- Control animals:
- no
- Details on study design:
- All animals were observed frequently on day of dosing and daily thereafter for at least 13 days after treatment for a total of 14 days. Day of treatment = day 0.
Daily observations included signs of toxicity in addition to lethality.
Animals weighed on a weekly basis.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 437.5 - < 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 250 mg/kg bw
- Based on:
- test mat.
- Mortality:
Dose (mg/kg).................................................... Males.........................................Females
125 0/5 0/5
250 0/5 2/5
375 0/5 n/a
437.5 1/5 n/a
500 4/5 5/5
2000 5/5 5/5- Clinical signs:
- No clinical signs in males or females at 125mg/kg immediately after treatment or during the 2 wk observation period.
Clinical signs in males and females at 250mg/kg or higher included decreased activity, jerks, tremors, ataxia, salivation, hunched posture, rales, blinking, red discharge from nose and mouth rough coat and increased activity.
In addition the following were noted in males:
squinting in a single animal at 250mg/kg.
small amount of stool under the cage of a single animal at 437.5mg/kg
Sneezing, excessive grooming and vocalizaation in a second animal also at 437.5mg/kg.
Red discharge eyes in several animals at 500 or 2000 mg/kg. - Body weight:
- No apparent treatment related body weights changes were observed in rats during week one or two of the observation period following treatment.
- Gross pathology:
- No gross morphological abnormalities observed in rats necropsied following acute death or in animals euthanized and necropsied at the end of the two wk observation period..
- Other findings:
- The acute oral approximate no-observed-effect-level (ANOEL) of Abbott 172245 in rats was found to be 125 mg/kg.
Applicant's summary and conclusion
- Conclusions:
- The approx oral LD50 was determined to be 250mg/kg in females and between 437.5 and 500mk/kg in males
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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