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EC number: 430-910-7 | CAS number: 13335-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 16-23 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out in accordance with method C7 of commission directive 92/69/EEC and in accordance with GLP. The test material was well characterised
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 430-910-7
- EC Name:
- -
- Cas Number:
- 13335-71-2
- Molecular formula:
- Hill formula: C10H12O3 CAS formula: C10H12O3
- IUPAC Name:
- 2-(2,6-dimethylphenoxy)acetic acid
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
acetylsalicylic acid
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration of A-172245.0 in samples were determinded by a High performance Liquid Chromatography method with UV detection (HPLC-UV).
5 sets of calibration sampels were prepared corresponding to 5 nomila concentrations:
0.010, 0.025, 0.050, 0.075 and 0.1 g/L
samples were take at 0,2,4,6,24,48 and 120 hours after preparation - Buffers:
- pH 4 buffer solution:
prepared by mixing 4.0 mL of 0.1 N NaOH with 500 mL of 0.1 M potassium hydrogen phthalate. MilliQ watr was added to reach a final volume of 1000 mL
pH 7 Buffer solution
Prepared by mixing 296.3 mL of 0.1 N NaOH with 500 mL of 0.1 M potassium dihydrogen phosphate (Kh2PO4). MilliQ water was added to reach a final volume of 1000ml
pH 9 Buffer solution
Prepared by mixing 213.0 ml of 0.1 N NaOH with 500 ml of 0.1 M boric acid. MilliQ water was added to reach a final volume of 1000 mL.
weighted amounts of A-172245.0 (about 25 mg) were solubilized in appropiate volumetric flasks in each buffer solution (pH 4,7 and 9, 50 ml) obtaining concentrations of about 0.5 mg/mL - Details on test conditions:
- performed at 50 C and pH 4,7 and 9
Duration of testopen allclose all
- Duration:
- 120 h
- pH:
- 4
- Initial conc. measured:
- >= 0.5 mg/L
- Duration:
- 120 h
- pH:
- 7
- Initial conc. measured:
- >= 0.5 mg/L
- Duration:
- 120 h
- pH:
- 9
- Initial conc. measured:
- >= 0.5 mg/L
- Number of replicates:
- five
- Negative controls:
- yes
- Remarks:
- buffer solution at pH 4,7,9
Results and discussion
- Preliminary study:
- For all 3 buffer solutions the A-172245.0 half life observed was higher than 2.4 hours. In addition, the results obtained in anlysis of the test samples at 120 hours indicated that the test substance degraded les tha 10%, suggesting that its half life cycle may be assumed to behigher than 1 year in all media assayed.
- Test performance:
- All concentrations assayed showed accuracy and precision values within the acceptance intervals of 85-115% and 0-15% respectively.
- Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- no reference to transformation products
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Details on results:
- An abiotic degradation study was carried out on A-172245.0 at three different pH values (4, 7 and 9) and at the temperature of 50 +/- 1 °C to evaluate the constant of hydrolysis and the half-life values. A Preliminary test was carried out to evaluate whether the half-life values were lower than 1 day or higher than 1 year for the three pH values. The degradation curves obtained in this test indicated that A-172245.0 was not significantly hydrolyzed in the conditions applied. On the basis of the data obtained, the degradation half-life was assumed to be higher than 1 year in the environment.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Test material is predicated to have a degradation half-life of longer than one year in conditions in the environment.
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