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Diss Factsheets
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EC number: 201-166-9 | CAS number: 79-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Results issued from reviewed document but only a brief summary was available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
- Principles of method if other than guideline:
- The method was not described.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,1,2-trichloroethane
- EC Number:
- 201-166-9
- EC Name:
- 1,1,2-trichloroethane
- Cas Number:
- 79-00-5
- Molecular formula:
- C2H3Cl3
- IUPAC Name:
- 1,1,2-trichloroethane
- Details on test material:
- Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- O.F.A. Iffa-Crédo (130-200g body weight)
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Each independent exposure chamber received a conditioned laminar air flow (24± 1 °C, 50± 2 % relative humidity). The air flow to each exposure chamber was approximately 12 m3/h. The exposure chambers were in a constant under-pressure of about 3mm water column. Micropumps with a variable volume conveyed the 1,1,2-trichloroethane to the injector located near the entrance of the exposure chamber. The injector vaporized the 1,1,2-trichloroehtane by heating controlled by a thermostat. Rats were only introduced into the exposure chamber (using an air-lock) when the targeted concentration was reached.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Samples of the test atmosphere were collected regularly (every 3 min.) from the exposure chamber and analyzed using gas chromatography.
- Duration of exposure:
- 6 h
- Concentrations:
- Geometric series (factor 1.05-1.1). Concentration range was set based on a range-finding experiment using 3 rats/dose and a geometric concentration series (factor 2)
- No. of animals per sex per dose:
- 12
- Control animals:
- not specified
- Details on study design:
- A range-finding study (3 rats/dose) preceded the main study. In the rang-finding study the concentrations were set according to a geometric series (factor 2). In the main experiment (12 rats/dose) the concentrations were set according to a geometric series (factor 1.05-1.1). Rats were exposed during 6h and the follow-up period was 14 days. There rats were frequently observed during exposure. Rats were weighed before exposure, and on day 7 and 14 post-exposure. A macroscopic evaluation of the lung, liver and kidneys was performed on the rats surviving the 14 day exposure period. In case of abnormal findings tissues were collected for microscopic evaluation.
- Statistics:
- The LD50 values and the 95% confidence interval were calculated according to the method of Bliss (Quart. U. Pharm. Pharmacol, 1938,2, 192-216). Weighted Linear regression with log-transformed concentrations on X-axis, and probit-transformed lethality on Y-axis.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 9 000 mg/m³ air
- Exp. duration:
- 6 h
- Mortality:
- Mortality was primarily observed during the 6h exposure period or during the first 24h following exposure. Some mortality was still observed between the 2nd till the 8th day post-exposure.
- Clinical signs:
- other: exitation, somnolent
- Body weight:
- A reduction of the body weigt gain was observed.
- Gross pathology:
- none of the rats surviving the 14 day follow-up period showed abnormal macroscopical findings.
- Other findings:
- -
Any other information on results incl. tables
The LC50 was reported to be 1654 ppm, the 95% confidence interval being 1586 -1725 (equivalent to 9 g/m3, 95% confidence interval: 8.6 -9.4 ).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 with rats exposed for 6 hours was reported to be 9 g/m3.
- Executive summary:
The LC50 with Sprague Dawley male rats exposed for 6 hours was reported to be 9 g/m3.
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