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Diss Factsheets
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EC number: 202-704-5 | CAS number: 98-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data sheet with overview of serveral studies, no full test report available. However, all relevant information is given. Therefore, the study can be regarded as valid for assessment.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male albino rats were exposed for 28 d to 3 concentrations of cumene (10 animals per group) and one control. Substance was given as 2% corn oil solution and blended with the basal laboratory ration. Survival, food consumption, organ weights and terminal body weights were evaluated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cumene
- EC Number:
- 202-704-5
- EC Name:
- Cumene
- Cas Number:
- 98-82-8
- Molecular formula:
- C9H12
- IUPAC Name:
- isopropylbenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Albino rats, strain not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- 28d
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
250, 2500, and 6000 ppm.
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
22.8, 224.8, and 535.8 mg/kg/d
Basis:
actual ingested
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- > 535.8 mg/kg bw/day (actual dose received)
- Sex:
- male
- Basis for effect level:
- other: No effects were observed in study. Only significant finding was increased testis at 224.8 mg/kg/d, however, there was no dose-response relationship.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Mortality |
Organweights ratio (%) |
Terminal body weights (g) |
||||
Dose (ppm) |
Liver |
Kidney |
Adrenals (mg%) |
Testes |
||
Control |
0 |
4.92 |
0.88 |
19 |
0.97 |
284 ± 16 |
250 |
0 |
4.26 |
0.91 |
18 |
1.09 |
276 ± 34 |
2500 |
0 |
4.27 |
0.89 |
17 |
1.12* |
283 ± 18 |
6000 |
0 |
4.19 |
0.91 |
18 |
1.04 |
267 ± 25 |
* Statistically significant difference (p>0.05) compared to control
No deaths ocured during the study and no untoward behavioral reactions were noted.
Body weight gain and food consumption over the course of the study is listed in figure in the report and showed no dose-response relationship.
At autopsy, no significant gross lesions were noted among rats when compared to control rats.
Applicant's summary and conclusion
- Conclusions:
- No NOEL could be established in this study, as no effects occured during the exposure period of 28d. The only significant finding was increased testis at medium dose, however this effects showed no dose response relationship.
- Executive summary:
Male albino rats were exposed for 28 d to 3 concentrations of cumene (10 per group) and one control. Substance was given as 2% corn oil solution and blended with the basal laboratory ration. Based on food consumption the daily intake was 22.8, 224.8, and 535.8 mg/kg/d. Survival, food consumption, organ weights and terminal body weights was not affected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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