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EC number: 443-510-2 | CAS number: 738587-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study Experimental phase 2002-09-20 to 2003-02-05. Report Date 2003-04-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets the criteria for classification as Reliable without restriction according to Klimisch et al (1997)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 443-510-2
- EC Name:
- -
- Cas Number:
- 738587-10-5
- Molecular formula:
- C26H14N10Ni2O18S4 as free acid
- IUPAC Name:
- dinickel(2+) sodium 3-carboxy-5-[(1E)-2-(7-oxido-2,6-disulfonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide 3-carboxy-5-[(1E)-2-(7-oxido-2-sulfo-6-sulfonatonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Buffers:
- - pH 4.0 Buffer Solution
164ml of 0.2M acetic acid solution added to 36ml of 0.2M sodium acetate solution and diluted to 1 litre with distilled/deionised water. Measured pH = 4.01
- pH 7.0 Buffer solution
296ml of 0.1M sodium hydroxide solution added to 500ml of 0.1M monopotassium phosphate solution and diluted to 1 litre with distilled/deionised water. Measured pH = 7.05
- pH 9.0 Solution
0.1M sodium hydroxide solution, pH adjusted to 9 with 0.1M hydrochloric acid. Measured pH = 9.10
All buffer solutions were degassed with helium before use. - Details on test conditions:
- Preparation of Test Solutions
The tests were prepared in duplicate in each buffer solution at around 0.5 g/L and placed in an oven at 50 +/-1 degree C. Analysis of the tests (by HPLC) was carried out initially and then over several days.
Duration of testopen allclose all
- Duration:
- 7 d
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- 5.13 g/L
- Duration:
- 7 d
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- 4.9 g/L
- Duration:
- 7 d
- pH:
- 9
- Temp.:
- 50
- Initial conc. measured:
- 5.36 g/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Preliminary study:
- Less than 10% hydrolysis had occured at pH 4, 7 and 9 after five days storage at 50 +/-1 degree C therefore no further testing was carried out.
- Transformation products:
- no
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 98.1
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 98.5
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 100.2
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 103.8
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 101.1
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 102.1
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Details on results:
- Less than 10% hydrolysis had occurred in the preliminary study at all three pH's after 5 days storage at 50°C ± 1 deg C therefore, no further testing was carried out.
Applicant's summary and conclusion
- Conclusions:
- In conclusion less than 10% hydrolysis had occurred in the preliminary study at pH 4, 7 and 9 after 5 days storage at 50°C ± 1 deg C.
- Executive summary:
Introduction
This study was undertaken to assess the hydrolysis of the test substance at different pH values.
Results & Conclusions
After 5 days <10% hydrolysis occured at pH's 4, 7 and 9 therefore, no further work was carried out.
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