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EC number: 200-875-0 | CAS number: 75-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: accepatable, well-documented publication, which meets basic scientific principles, see also 7.8.2
- Remarks:
- The route of exposure (i.p.) is not standard. beside that an acceptable, well-documented publication which meets basic scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Devepolmental toxicity of methylamines in mice
- Author:
- Guest, I., Varma, D.R.
- Year:
- 1 991
- Bibliographic source:
- Journal of Toxicology and Environmental Health, 32:319-330, 1991
Materials and methods
- Type of study / information:
- Exploration if chronic administration of methylamines can cause reproductive toxicity using pregnant CD-1mice and mouse embryos in culture as experimental models.
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 414
- GLP compliance:
- no
Test material
- Reference substance name:
- Trimethylamine
- EC Number:
- 200-875-0
- EC Name:
- Trimethylamine
- Cas Number:
- 75-50-3
- Molecular formula:
- C3H9N
- IUPAC Name:
- N,N-dimethylmethanamine
- Details on test material:
- CAS 75-50-3 (trimethylamine), purity not specified.
Constituent 1
Results and discussion
Any other information on results incl. tables
A concentration related decrease of yolk-sac diameter,
paleness of the yolk-sac, crown-rump length, head length,
somite number and survival was seen in all treatment groups.
At 0.5 mM and above development of the forelimb and the
brachial bar was retarded.
Up to 0.75 mM neuropores closed well.
Up to 1 mM heart development was unaffected.
At 1 mM only 33% of the embryos was dorsally convex.
Concentration related decreases of embryonal RNA, DNA and
protein were seen.
In vitro studies: all three methylamines produced concentration-dependent decreases in yolk-sac diameter, crown-rump length, head length, and fetal survival; developmental score and somite number also exhibited a similar concentration-dependent decrease.
The effect of all the three methylamines was more marked on the head length than on crown-rump length and yolk-sac diameter.
The external appearance of embryos was not affected by low concentrations of methylamines. at higher concentrations (> 0.5 mM), there appeared to be a dispropotionate retardation in forelimb and branchial bar development relative to the development of other organs. All embryos were dorsally convex at 1 mM MMA or DMA.
The development of hearts was unaffected at concentrations up to 1 mM of all 3 methylamines and neuropores closed well up to concentrations of 0.75 mM.
All three methylamines produced concentration-dependent decreases in embryo RNA, DNA and proteins; the realtive order of toxicity was the same as in vivo, namely TMA> DMA > MMA.
- all three methylamines possess teratogenic potential in varying degrees.
Applicant's summary and conclusion
- Conclusions:
- At all tested concentrations teratogenic potential was
demonstrated.
- The NOAEL for maternal and developmental toxicity, including teratogenicity, was 155 mg/kg bw based on the absence of any adverse findings at this dose - Executive summary:
Reproductive toxicity
In a toxicity study in mice no effect of intraperitoneal monomethylamine hydrochloride administration (from day 1 to 17 of gestation) on body weights and food consumption of the females and on organ weights were observed up to 115 mg/kg bw. From the above, it was considered that reproductive/developmental toxicity NOEL is 225.4 mg/kg bw/day for female mice.
Developmental toxicityA study performed by Guest et al. in 1991, dealt with the investigation of maternal or fetal effects after administration of MMA via intraperitoneal injection. The number of resorbed and dead fetuses were equally distributed across all doses of MMA, and, therefore, is considered to not be treatment related.None of the amines (MMA, DMA, TMA) caused a significant increase in external, internal organ, or skeletal abnormalities, but all three possess a teratogenic potential in varying degrees.Monomethylamine did not exert any fetal effects at the highest dose level tested.In vitro, all three methylamines produced concentration-dependent decreases in yolk-sac diameter, crown-rump length, head length, and fetal survival; developmental score and somite number also exhibited a similar concentration-dependent decrease. The external appearance of the embryos was not affected by low concentrations of methylamines, but at higher concentrations (> 0,5 mM), there appeared a dispropotionate retardation in the forelimb and branchial bar development relative to the development of other organs. SoMMA inhibits development of mouse embryos in culture.
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