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Diss Factsheets
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EC number: 203-545-4 | CAS number: 108-05-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, non-guideline, animal experimental study, published in peer reviewed literature, limitations in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- The assay of acute vapour toxicity and the grading and interpretation of results on 96 chemical compounds
- Author:
- Carpenter CP, Smyth HF Jr and Pozzani UC
- Year:
- 1 949
- Bibliographic source:
- J. Ind. Hyg. Toxicol. Vol 32, p 343-346
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- yes
- Remarks:
- Older study, describes a grading system for acute inhalation exposures, based on concentration causing mortality. No clin obs or pathology reported.
- Principles of method if other than guideline:
- Exposures to known concentrations to evaluate relative toxicity independently of vapour pressure. Constant exposure time of 4 hours. Concentration varied increasing by a factor of 2 until the concentration killing 2, 3, or 4 of 6 rats within a 14-day observation period obtained.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Vinyl acetate
- EC Number:
- 203-545-4
- EC Name:
- Vinyl acetate
- Cas Number:
- 108-05-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- ethenyl acetate
- Details on test material:
- - No details reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Own colony (Mellon Institute, University of Pittsburgh, Pennsylvania, USA
- Age at study initiation: no data
- Weight at study initiation: 100-150 g
- no further details reported
ENVIRONMENTAL CONDITIONS
- no data
IN-LIFE DATES:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: All glass vessels
- The vapour concentration was prepared by delivering the fluid sample into an evaporator through which metered air was forced. The rate of flow of the dilution air was measured by a Fischer-Porter “Rotameter” covering a range of 0.5 to 30 liters/minute. The vapours were carried to the exposure chamber by the counter current of dilution air entering the bottom of the evaporator having passed through a desiccator.
TEST ATMOSPHERE
- No analytical checks were made on the concentration of the vapour prepared. The concentrations were based on empirical calculations. Observation of the flowmeter readings, Monodrum delivery and vaporizer performance was used to eliminate errors.
- Rationale for the selection of the starting concentration: The equipment utilized for the vapour exposures was not explosion-proof and concentrations were therefore kept below the lower explosive limit. - Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- The concentrations were based on empirical calculations.
- Duration of exposure:
- 4 h
- Concentrations:
- 4000 ppm
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - During exposure: time of onset of clinical signs recorded
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: At termination
- Necropsy of survivors performed: yes, gross pathology and selected tissues for histopathology
- Other examinations performed: clinical signs - Statistics:
- A grading system for acute (4 hour) inhalation exposures is based on the concentration causing mortality. Grades 1 - 5 indicate a slight hazard, grades 6 - 9 a moderate hazard, grades 10 -13 a definite hazard and grades 14 -19 a serious hazard.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: Degree of hazard: Moderate
- Effect level:
- 4 000 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: 14084 mg/m3; (The conversion of ppm to mg/m3 is based on Rm of 86.09, 25 deg C, 1 atmosphere.) 2, 3 or 4/6 animals died post exposure
Applicant's summary and conclusion
- Interpretation of results:
- other: Defined as moderate by the authors in this older study
- Remarks:
- Criteria used for interpretation of results: other: Based on older 19-point grading system
- Conclusions:
- Exposure to vinyl acetate for 4 hours at 4000 ppm (range 2800 -5500 ppm) has a moderate degree of hazard.
- Executive summary:
Exposures to known concentrations of vinyl acetate for 4 hours were used to evaluate its relative toxicity independently of vapour pressure and the concentration killing 2, 3, or 4 of 6 rats within a 14-day observation period was obtained. On this basis, vinyl acetate was considered to have a moderate degree of hazard with 4000 ppm killing up to 4/6 rats following 4 hours of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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