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Diss Factsheets
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EC number: 203-631-1 | CAS number: 108-94-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acute not harmful to aquatic invertebrates
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 207 mg/L
Additional information
Two publications by Bringmann and Kuehn (1982, 1977) indicate that cyclohexanone is acutely not harmful to Daphnia. The 24h-EC50 values are 800 mg/L and 820 mg/L, respectively. Both studies were performed similar to German industrial standard, with a test period of 24 h and without analytical controls. Nevertheless these limitations were considered in a validity score of 2 (valid with restrictions), which is in the line with the validation in the ICCA SIDS program. The validity without analytical monitoring is reasonable, since cyclohexanone can be supposed as stable under the test conditions and the volatilization of cyclohexanone is negligible. Cyclohexanone has a Henry’s Law constant of 1.3 Pa/m³ mol and has therefore a low tendency to escape from the water phase.
The very low acute toxicity of cyclohexanone to aquatic invertebrates is confirmed by the results of an estmation conducted with the QSAR Toolbox (v4.3.1) using trend analysis within category members. The estimated EC50 of 207 mg/L is considered reliable and is taken, as a worst case, as key value for the chemical safety assessment.
A further indication of the low acute toxicity of cyclohexanone is supplied by the result of an investigation conducted with the very similar substance cyclopentanone (CAS No. 120 -92 -3). Both substances are saturated alicyclic ketones, whose only difference consists in a methylene group. The relevant physico-chemical properties are similar as well. The acute toxicity study on cyclopentanone to Daphnia magna was carried out in accordance with the OECD Guideline 202 (Rhodia, 2003). The principles of Good Laboratory Practices were fulfilled. For cyclopentanone no immobilisation was observed at the tested concentrations up to 100 mg/l at time 0; 24 and 48 hours. At the end of the test duration the recovery rate of the test item was > 80 % so that volatilisation can be excluded under the test conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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