Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-679-5 | CAS number: 68-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
- Report date:
- 1952
- Reference Type:
- publication
- Title:
- OECD SIDS Dimethylformamide, Final April 2004
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- OECD SIDS Dimethylformamide
Materials and methods
- Principles of method if other than guideline:
- - Principle of test: BASF method.
- Short description of test conditions: A patch is soaked with DMF and applied onto the skin on the back of the rabbits and fixed with a bandage. The neat test substance (about 0.5 mL) was administered for 20 hours. After bandage removal the application site was examined. In case of symptoms, examination was performed further until the findings disappeared.
- Parameters analysed / observed: Application site (erythema and edema score) - GLP compliance:
- no
- Remarks:
- The study was performed prior to the adoption of GLP compliance.
Test material
- Reference substance name:
- Dimethylformamide
- IUPAC Name:
- Dimethylformamide
- Reference substance name:
- N,N-dimethylformamide
- EC Number:
- 200-679-5
- EC Name:
- N,N-dimethylformamide
- Cas Number:
- 68-12-2
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N,N-dimethylformamide
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylformamide
- Analytical purity: 99%,
- Impurities (identity and concentrations): about 1 % Methanol, traces of Monomethylformamide and Formamide
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- data not available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): undiluted and as 50 % solution in water. - Duration of treatment / exposure:
- 20 hours
- Observation period:
- 48 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: shaved back of albino rabbits.
- % coverage: 2.5 cm X 2.5 cm big patch
- Type of wrap if used: patch fixed with a bandage.
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 20 h
OBSERVATION TIME POINTS
(indicate if minutes, hours or days): 24h, 24h/48
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.25
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: 72 h data missing
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 72 h data missing
- Irritant / corrosive response data:
- Only one of the four animals showed faint redness on the first day after removal of the bandage.
- Other effects:
- no
Any other information on results incl. tables
Mean erythema score after 24 and 48 h (72 h data is missing); (animal 1/animal 2):
Conc. | 24 h | 48 h | mean |
100% | 1/0 | 0/0 | 0.5/0 |
50% | 1/0 | 0/0 | 0.5/0 |
Mean edema score after 24 and 48 h (72 h data is missing); (animal 1/animal 2):
Conc. | 24 h | 48 h | mean |
100% | 0/0 | 0/0 | 0/0 |
50% | 0/0 | 0/0 | 0/0 |
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Remarks:
- EU GHS criteria not met
- Conclusions:
- Only one animal showed faint redness on the first day after removal of the bandage. On the second day there were no more findings. The other animal was without any findings. Under the present test conditions DMF was not irritating.
- Executive summary:
Study design
This non-GLP in vivo study was performed comparable with OECD guideline study. The neat substance (about 0.5 mL) was administered for 20 hours on the shaved back of 4 albino rabbits. For this purpose a 2.5 cm x 2.5 cm big patch was soaked with the test substance and applied onto the skin and fixed with a bandage. After removal of the bandage the application site was examined and in case of findings, observation continued until the findings disappeared.
Results
Only one animal showed faint redness on the first day after removal of the bandage. On the second day there were no more findings. The other animal was without any findings.
Conclusion
Under the present test conditions DMF was not irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.