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EC number: 234-541-0 | CAS number: 12008-41-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA (40 CFR)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium octaborate
- EC Number:
- 234-541-0
- EC Name:
- Disodium octaborate
- Cas Number:
- 12008-41-2
- Molecular formula:
- Na2B8O13
- IUPAC Name:
- disodium bis[(oxoboranyl)oxy]bicyclo[5.5.1]hexaboroxane-3,5-bis(olate)
- Details on test material:
- - Name of test material: 20 MULE TEAM TIM-BOR
- Physical state: White powder
- Analytical purity: > 98 %
- Lot/batch No.: 8E25H
- Stability under test conditions: Stable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Approved USDA source
- Weight at study initiation: Males 262 –371g; Females 226 –275 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % w/v - Doses:
- 1.25; 2.0; 3.15; 5.0 g/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: No data
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs and body weight - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 550 mg/kg bw
- 95% CL:
- >= 2.1 - <= 3.1
- Remarks on result:
- other: According to the method of Litchfield and Wilcoxon
- Mortality:
- At 5.0 g/kg ten deaths occurred between days 0 and 2 of the observation period.
At 3.15 g/kg six deaths occurred between days 1 and 3 of the observation period.
At 2.0 g/kg four deaths occurred on day 1 of the observation period.
At 1.25 g/kg there were no deaths. - Clinical signs:
- other: At 5.0 g/kg the following clinical changes were observed: Mild to extreme depression, fecal stains, loose mucoid faeces on cage paper, urine stains, piloerection, eye squinting and scruffy hair coats. At 3.15 g/kg the following clinical changes were obser
- Gross pathology:
- Pathological changes in the animals that died included darkened, reddened pale and/or mottled lungs; congested, mottled or pale kidneys, mottled and/or pale liver and spleens; pale intestines filled with clear yellow liquid; pale pancreas and green watery fluid in stomach and partially distended stomach which reduced in severity with reducing dose
Any other information on results incl. tables
Cumulative mortality data for male and female rats treated orally with 20 MULE TEAM TIM-BOR:
Dosage (g/kg) |
Cumulative No. of deathsa |
||||||||
Observationsb |
Observations day after treatment |
||||||||
A |
B |
C |
1 |
2 |
3 |
4 |
7 |
14 |
|
Males |
|||||||||
5.0 |
0 |
0 |
0 |
3 |
5 |
5 |
5 |
5 |
5 |
3.15 |
0 |
0 |
0 |
1 |
2 |
4 |
4 |
4 |
4 |
2.0 |
0 |
0 |
0 |
2 |
2 |
2 |
2 |
2 |
2 |
1.25 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Females |
|||||||||
5.0 |
0 |
0 |
2 |
5 |
5 |
5 |
5 |
5 |
5 |
3.15 |
0 |
0 |
0 |
2 |
2 |
2 |
2 |
2 |
2 |
2.0 |
0 |
0 |
0 |
2 |
2 |
2 |
2 |
2 |
2 |
1.25 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
a Five animals per dose per group.
b A = 1 3/4 - 2 h; B = 3 1/4 - 5 3/4 h; C = 6 - 6 3/4 h.
Body weight gain in male and female rats terated orally with 20 MULE TEAM TIM-BOR:
Animal No. |
Sex |
Body weight gain (g) Day 0 - 14 |
0.5 g/kg group |
||
1-7675 |
M |
ND |
2-7686 |
M |
ND |
3-7700 |
M |
ND |
4-* |
M |
ND |
5-* |
M |
ND |
6-7734 |
F |
ND |
7-7737 |
F |
ND |
8-7753 |
F |
ND |
9-7763 |
F |
ND |
10-* |
F |
ND |
3.15 g/kg group |
||
1-7683 |
M |
ND |
2-7688 |
M |
ND |
3-* |
M |
69 |
4-* |
M |
ND |
5-* |
M |
ND |
Mean (S.D.) |
69 |
|
6-7730 |
F |
74 |
7-7736 |
F |
21 |
8-7744 |
F |
ND |
9-4449 |
F |
38 |
10-* |
F |
ND |
Mean (S.D.) |
44 (27) |
|
2.0 g/kg group |
||
1-7695 |
M |
48 |
2-* |
M |
89 |
3-* |
M |
ND |
4-*- |
M |
101 |
5-* |
M |
ND |
Mean (S.D.) |
79 (28) |
|
6-7741 |
F |
43 |
7-7751-D |
F |
ND |
8-7752 |
F |
54 |
9-* |
F |
ND |
10-* |
F |
39 |
Mean (S.D.) |
45 (8) |
|
1.25 g/kg group |
||
1-7684 |
M |
78 |
2-* |
M |
125 |
3-* |
M |
85 |
4-* |
M |
82 |
5-* |
M |
82 |
Mean (S.D.) |
90 (20) |
|
6-7729 |
F |
34 |
7-7756 |
F |
55 |
8-* |
F |
47 |
9-* |
F |
45 |
10-* |
F |
40 |
Mean (S.D.) |
44 (8) |
Applicant's summary and conclusion
- Interpretation of results:
- other: EU GHS criteria not met
- Conclusions:
- The acute oral LD50 for males and females was 2550 mg/kg bw.
- Executive summary:
The test item disodium octaborate tetrahydrate was assessed for oral acute toxicity in rats in a GLP study according to OECD Guideline 401. Five animals per sex per dose were exposed via gavage to doses of the test item (50% in water) of 1.25; 2.0; 3.15 and 5.0 g/kg bw. The acute oral LD50 for males and females was 2550 mg/kg bw.
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