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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-633-5 | CAS number: 123-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Sensory response to certain industrial solvent vapors
- Author:
- Nelson KW et al.
- Year:
- 1 943
- Bibliographic source:
- J . ind. Hrg. Toxicol. 25, 282
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs - Isoamyl alcohol
- Author:
- Opdyke DLJ
- Year:
- 1 978
- Bibliographic source:
- Food Chem. Tox. 16, S1, 785-788
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Rowe and McCollister
- Year:
- 1 982
- Bibliographic source:
- Patty's Ind. Hyg. Toxicol., 3rd ed., vol 2, page 2658
Materials and methods
- Type of study / information:
- Inhalation study
- Endpoint addressed:
- respiratory irritation
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methylbutan-1-ol
- EC Number:
- 204-633-5
- EC Name:
- 3-methylbutan-1-ol
- Cas Number:
- 123-51-3
- Molecular formula:
- C5H12O
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Isoamyl alcohol
- Analytical purity: no data
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- The procedure followed in this study consisted of the exposure of an average number of ten persons, of mixed sexes, to a given concentration of solvent vapour for a period of 3 to 5 min, in a 1200 cubic foot gas cabinet.
After the exposure, each individual classified the effect of the vapour on the eyes, nose, and throat. The classifications were: no reaction, slightly irritating, and very irritating.
The odor was listed as absent, definite, moderate, strong, or overpowering.
Finally, each person was asked if he believed he could work in the atmosphere for an eight-hour day. - Exposure assessment:
- not specified
- Details on exposure:
- TYPE OF EXPOSURE: inhalation
EXPOSURE LEVELS: 100 - 150 ppm (corresponding to approx. 0.366 - 0.549 mg/L)
EXPOSURE PERIOD: 3 - 5 min
Results and discussion
- Results:
- Irritating to the throat at 100 ppm (equivalent to approx. 0.366 mg/L) and to the eyes and nose at 150 ppm (equivalent to approx. 0.549 mg/L).
The highest concentration which the majority of subjects estimated as acceptable for an 8-hour exposure was < 100 ppm (equivalent to approx. 0.366 mg/L).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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