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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-436-9 | CAS number: 95-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Phototransformation in air
Administrative data
- Endpoint:
- phototransformation in air
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data are taken from published, peer-reviewed journal articles. The data are presented in review articles and no information is available on the data sources.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Gas-phase tropospheric chemistry of organic compounds: a review
- Author:
- Atkinson R
- Year:
- 1 990
- Bibliographic source:
- Atmospheric Environment. 24A (1): 1-41
Materials and methods
- Principles of method if other than guideline:
- Guideline not stated. Kinetic data taken from Atkinson R (1990). Kinetics and mechanisms of the gas-phase reactions of the hydroxyl radical with organic compounds. Journal of Physical and Chemical Reference Data.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,4-trimethylbenzene
- EC Number:
- 202-436-9
- EC Name:
- 1,2,4-trimethylbenzene
- Cas Number:
- 95-63-6
- Molecular formula:
- C9H12
- IUPAC Name:
- 1,2,4-trimethylbenzene
- Details on test material:
- No data reported
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Study design
- Estimation method (if used):
- The half-life of 1,2,4-trimethylbenzene was calculated using the formula: half-life = ln2/(rate constant*OH concentration*time) where the OH concentration is 5E+05 and the time is 86400 seconds.
- Light source:
- not specified
- Details on light source:
- No data reported
- Details on test conditions:
- Kinetic data taken from Atkinson R (1990). Kinetics and mechanisms of the gas-phase reactions of the hydroxyl radical with organic compounds. Journal of Physical and Chemical Reference Data.
- Reference substance:
- not specified
Results and discussion
- Preliminary study:
- The kinetic rate constant for the reaction of 1,2,4-trimethylbenzene with OH radicals is measured to be 32.5 E+12 cm3/mol/s.
- Test performance:
- The atmospheric half-life of 1,2,4-trimethylbenzene is calculated to be approximately 12 hours.
% Degradation
- % Degr.:
- 50
- Sampling time:
- 12 h
Degradation rate constant
- Reaction with:
- OH radicals
- Rate constant:
- 0 m³ molecule-1 s-1
- Transformation products:
- not specified
- Results with reference substance:
- Not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The kinetic rate constant for the reaction of 1,2,4-trimethylbenzene with OH radicals is measured to be 32.5-40 E+12 cm3/mol/s, indicating that the atmospheric half-life would be 12 hours.
- Executive summary:
Atkinson (1990) is a review article, with no data reported on the test methods or conditions of the original data source. Never-the-less, the data are taken from a published, peer-reviewed journal article and are considered to be suitable as supporting data for this endpoint. The measured results provide a rate constant of the reaction of 1,2,4 -trimethylbenzene with OH radicals of 32.5 E+12 cm3/mol/s. The results indicate that the substance would have an atmospheric half-life of approximately 12 hours and therefore would not be persistent in the atmospheric compartment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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