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Diss Factsheets
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EC number: 252-777-2 | CAS number: 35884-66-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 November - 16 December 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guidelines/standards.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute Skin Absorption LD50 Test on Rabbits
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrakis(tritolyl phosphite )nickel
- EC Number:
- 252-777-2
- EC Name:
- Tetrakis(tritolyl phosphite )nickel
- Cas Number:
- 35884-66-3
- Molecular formula:
- C84H84NiO12P4
- IUPAC Name:
- tetrakis(tris(4-methylphenyl) phosphite) nickel
- Details on test material:
- - Name of test material (as cited in study report): Nickel, tetrakis[tris(3-methyl-phenyl) phosphite-P]-, mixture with tetrakis[tris(4-methylphenyl)phosphite-P]nickel
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- See below.
- Duration of exposure:
- 24 h
- Doses:
- 1000, 1500, 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- The LD50 value was calculated from mortality data, using the method of D. J. Finney:
Finney, D. J., Probit Analysis, 3rd Ed., 1971, Cambridge University Press.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 129 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 613 - <= 1 424
- Remarks on result:
- other: (corresponding to 508 mg/kg bw for the submission substance)
- Mortality:
- See table below. All deaths occurred within 2 days after dosing.
- Clinical signs:
- other: Prostration at 1500 and 2000 mg/kg.
Any other information on results incl. tables
Dose as received Average wt (g)
Sex No. mg/kg Avg. mL Initial 14 Days Mortality (mg/kg)
Male 6 2000 5.05 2776 - 6/6 1129
6 1500 3.20 2344 2625 5/6
6
1000
2.06
2257
2631
2/6
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Single dermal application of the test material caused lethality in male rabbits, resulting in an LD50 of 1129 mg/kg bw (corresponding to 508 mg/kg bw submission substance only).
- Executive summary:
The test substance was subject to an acute dermal LD50 test on rabbits. Doses of 1000 to 2000 mg/kg were applied to intact skin under occlusive conditions for 24 hours. Deaths occured in all dose groups within 2 days after dosing. The LD50 is 1129 mg/kg bw, corresponding to 508 mg/kg bw for the submission substance only.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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