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Diss Factsheets
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EC number: 244-841-3 | CAS number: 22205-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 August 1977 to 22 August 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- other: read-across target
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted on read-across material
- Justification for type of information:
- Read-across to DOTI (Diisooctyl 2,2'-[(dioctylstannylene)bis(thio)]diacetate) (CAS 26401-97-8), see attached justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Remarks on result:
- other: When the air was saturated with the test material for a 7 hour treatment period, no mortality occurred.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- Diisooctyl 2,2'-[(dioctylstannylene)bis(thio)]diacetate
- EC Number:
- 247-666-0
- EC Name:
- Diisooctyl 2,2'-[(dioctylstannylene)bis(thio)]diacetate
- Cas Number:
- 26401-97-8
- Molecular formula:
- C36-H72-O4-S2-Sn
- IUPAC Name:
- 6-methylheptyl 14-methyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannapentadecan-1-oate
- Reference substance name:
- Mono-n-octyltin-tri-thioglycol-acid isooctyl ester
- IUPAC Name:
- Mono-n-octyltin-tri-thioglycol-acid isooctyl ester
- Test material form:
- liquid
- Details on test material:
- - Appearance: colourless liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: In house
- Weight at study initiation: 150 to 168 g (M) and 133 to 147 g (F)
- Fasting period before study: 16 hours before treatment
- Housing: Macrolon Type II cages, 1 animal per cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 to 23°C
- Humidity: 49 to 65 %
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- - The dynamically operated inhalation system consists of the generator unit for generating the inhaled air saturated with test material vapour and the exposure unit for the absorption and exposure of the test animals.
- The compressed air of the household network was passed through two parallel special gas washed bottles after passing through a fine dust filter, pressure stabiliser, volume regulator and volume meter. These washed bottles were each equipped with G1 glass frits.
- The filling quantity of the special gas washed bottles over the frit was kept constant by means of a level control. The washed bottles as well as a glass tube coil for temperature pre-stabilisation of the air were in a temperature-controlled water bath in which had a temperature of 20 ± 0.2°C was maintained.
- After leaving the gas washed bottles, the steam was now saturated with test material steam. Air passed into two tube-shaped inhalation chambers.
- These inhalation chambers consisted of a glass tube (diameter 150 mm, length 1000 mm) with detachable end pieces and an insertable grid frame, which subdivided the upper part of the glass tube into 10 segments (1 animal per segment). The grid frame was resting on a half-blade made of stainless steel for excrement recording. The air / steam mixture emanating from the chambers was passed into the flue.
- The temperature and relative humidity in the chambers were monitored. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- - Air was saturated with the test material
- No. of animals per sex per dose:
- 10 animals per sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- A relative humidity of 13% and a temperature of 20 to 21°C were measured in the chambers.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Remarks on result:
- other: When the air was saturated with the test material for a 7 hour treatment period, no mortality occurred.
- Mortality:
- No deaths occurred during the exposure or observation period.
- Clinical signs:
- other: In the 14-day observation period some animals showed conjunctivitis
- Body weight:
- - Group 1: Male mean body weight increased from 164 to 278 g during the study and female mean bodyweight increased from 139 to 199 g.
- Group 2: Male mean body weight increased from 158 to 275 g during the study and female mean bodyweight increased from 140 to 200 g. - Gross pathology:
- All male and female animals were suspected of slight thymus enlargement, which however can neither be quantified nor interpreted as a test material defect, since no control group was carried in the experiment.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the conditions of this study following a 7 hour treatment, no mortality occurred. In some animals, a temporary conjunctivitis was observed during the post-treatment period.
- Executive summary:
The acute inhalation toxicity of the test material was investigated in a study using male and female Wistar rats.
Animals whole bodies were continually exposed to the test material at steam saturated in air for a period of 7 hours in an inhalation chamber. They were observed during this treatment time and for 14 days afterwards.
No mortalities occurred during the treatment or observation periods. Some of the animals showed conjunctivitis during 14-day observation period. Body weights increased during the observation period.
Following the 14 days observation period the animals were sacrificed and necropsy performed. All animals were suspected of slight thymus enlargement, which however can neither be quantified nor interpreted as a test material defect, since no control group was carried in the experiment.
Under the conditions of this study following a 7 hour treatment, no mortality occurred. In some animals, a temporary conjunctivitis was observed during the post-treatment period.
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