Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 217-420-7 | CAS number: 1843-03-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The substance is considered persistent. The substance is not readily biodegradable (12% in 28 days). The extremely low water solubility prevents assessment of the hydrolysis of the substance by testing but assessment of the chemical structure suggests that the substance is stable and will not hydrolyse.
The substance is not bioaccumulative. The log Pow estimated by QSAR is 12.6962 by structural fragmentation by KOWWIN. Furthermore, the QSAR assessment of BCF by Arnot-Gobas BCF & BAF Methods estimated a BCF of 1.064 L/kg wet-wt.
The toxicokinetic data available on a close structural analogue conducted with a radioisotope demonstrates that the substance is not metabolised in a mammalian system and only trace levels absorbed to blood and tissues (0.06%) or excreted in urine. The data demonstrates that 28% was located in the GI tract with the total remaining mass balance (71%) excreted in faeces.
The substance is not toxic. The substance is highly water insoluble. In consequence exposure to three aquatic species has been investigated at nominal concentrations. The toxicological examination of freshwater fish, daphnia and algae resulted in no toxic effect and all data were completed as limit tests.
The substance has been assessed for genetic toxicity by three in vitro assays with and without metabolic activation. All three endpoints demonstrate a lack of mutagenic response.
The screening reproduction toxicity study on a close structural analogue demonstrates a lack of effects to parent and F1 animals with no effects to reproduction.
On the basis of the genetic and reproduction toxicity data available, in addition to the repeated dose toxicity data the substance is considered to not present the potential for carcinogenic hazard.
The data from one subchronic mammalian toxicity study are available by dietary exposure. The study achieved a NOAEL at 500 mg/kg/day with effects at high dose limited principally to reduced body weight gain due to reduced food intake and liver cytoplasmic vacuolation. The substance is not classified on the basis of these data and no further toxicological examination is considered necessary for hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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