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Diss Factsheets
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EC number: 203-812-5 | CAS number: 110-88-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline with acceptable restrictions (no purity of test substance listed)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- secondary source
- Title:
- 1,3,5-TRIOXANE, CAS Number 110-88-3, USEPA HPV Challenge Program Submission
- Author:
- Trioxane Manufacturers Consortium Members, BASF Performance Copolymers, LLC (Formerly Ultraform Company) and Ticona
- Year:
- 2 000
- Bibliographic source:
- USEPA Submission
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- (adopted 1981)
- GLP compliance:
- yes
- Remarks:
- (Bio/dynamics Inc)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3,5-trioxane
- EC Number:
- 203-812-5
- EC Name:
- 1,3,5-trioxane
- Cas Number:
- 110-88-3
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 1,3,5-trioxane
- Details on test material:
- - Name of test material (as cited in study report): Trioxane (C-235)
- Physical state: solid
- Lot/batch No.: 41115 AT
- Storage condition of test material: in a ventilated, temperature monitored room (15-29 °C)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories
- Age at study initiation: males 9 weeks, females 12 weeks
- Mean weight at study initiation:
Group I - males 338 g (310 - 360) females 230 g (220 - 245);
Group II - males 329 g (315 - 342) females 226 g (219 - 239)
- Diet (e.g. ad libitum): Purina Rodent Laboratory Chow
- Water (e.g. ad libitum): automated watering system
- Acclimation period: 28-30 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 100 L
- Source and rate of air: Chamber air was drawn through 1/4" Teflon line and regulated at a flow of 1 L/min for Group I or 0.5 L/min for Group II using a calibrated Dwyer flowmeter and Nupro metering valve. Chamber air was then directed to a glass "Y" tube where it was diluted with room air at a flow of 5 L/min. The resultant 5 to 1 chamber air dilution for Group I, or 10 to 1 chamber air dilution for Group II, was drawn into the Miran using a model Thomas 107CA 183 pump.
- Method of particle size determination: Particle size distribution samples were taken using a TSI Aerodynamic Particle Sizer equiped with a TSI Diluter.
- Temperature, humidity in air chamber: 24-27 °C, 40-48 %
TEST ATMOSPHERE
- Brief description of analytical method used: exposure levels were analysed using a Miran 1A Ambient Air Analyzer and a strip chart recorder.
- Samples taken from breathing zone: yes
- nominal cancentrations were determined by weighing.
TEST ATMOSPHERE
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 1.6/1.2 µm (exposure 1), 1.1/1 µm (exposure 2)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Initial dose: 8370 ppm, corresponding to 30.8 mg/l (measured).
Follow up dose: 10643 ppm, corresponding to 39.2 mg/l (measured), which was the maximum attainable vapour concentration. - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were observed individually, immediately prior to exposure, as a group at approximately 15-minute intervals during the first hour of exposure, and hourly thereafter. All animals were observed individually upon removal from the chamber (about one half-hour after exposure was completed) and at hours one and two post-exposure. Body weights were measured at day 1 (immediately prior to exposure), and on days 2, 3, 5, 8, and 15 (just prior to sacrifice).
- Necropsy of survivors performed: yes (including nasal passages, trachea, external surface, orifices, cranial cavity, carcass, brain, spinal chord, thoracic, abdominal and pelvic cavities and their viscera, cervical tissues and organs.
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 39.2 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortalities observed at the highest tested dose of 39.2 mg/l air.
- Mortality:
- No mortalities were observed.
- Clinical signs:
- other: Increased secretory response, respiratory distress, and general signs of poor condition were reported.
- Body weight:
- There was a compound-related reduction in body weight for both sexes following exposure (8 - 9%). Animals gained body weight normally during the second week of the observation period.
- Gross pathology:
- At necropsy, no treatment-related abnormalities were observed, and no target organs could be identified.
Any other information on results incl. tables
Test concentration |
8370 ppm ( i.e. 30.8 mg/l air) |
||
Symptom |
Onset |
Duration |
Affected animals/treated animals |
Lacrimation |
4 h |
14 days |
Few |
Shallow breathing |
4 h |
Less than 24 h |
6/10 |
Irregular breathing |
4 h |
2 days |
9/10 |
Reduced activity |
45 min. |
Less than 24 h |
Most |
Nasal discharge |
4 h |
14 days |
About the half |
10643 ppm (i.e. 39.2 mg/l air) |
|||
Lacrimation |
15 min. |
13 days |
Many |
Shallow breathing |
4 h |
Less than 24 h |
About the half |
Irregular breathing |
30 min. |
5 days |
All |
Reduced activity |
15 min. |
Less than 24 h |
All |
Nasal discharge |
4 h |
14 days |
Few to most |
Body weights (g) |
Test concentration |
|||||
8370 ppm ( i.e. 30.8 mg/l air) |
||||||
Time point (days) |
0 |
2 |
3 |
5 |
8 |
15 |
Males |
338 |
310 |
319 |
325 |
342 |
364 |
Females |
230 |
210 |
218 |
221 |
233 |
239 |
10643 ppm (i.e. 39.2 mg/l air) |
||||||
Males |
329 |
293 |
292 |
310 |
330 |
352 |
Females |
226 |
210 |
216 |
216 |
224 |
235 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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