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EC number: 418-480-9 | CAS number: 138526-69-9 1-BROM-3,4,5-TRIFLUORBENZOL; 1-BROMO-3,4,5-TRIFLUOROBENZENE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-09-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 1997
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil
- Radiolabelling:
- no
- Test temperature:
- 35 °C
- Details on study design: HPLC method:
- EQUIPMENTS
- Apparatus: HPLC system with Spectrophotometric detector
- Type, material and dimension of analytical column: Hypersil BDS-CN; column size: 150 x 4.6 mm; particle size: 5 µm, column temperature: 35 °C.
Detection: UV at A=210 nm
REAGENTS
Methanol: Labscan Limited Co., Dublin, Ireland
Acetonitrile: Labscan Limited Co.
Milli-Q water: Millipore Corp., Bedford, MA, USA
Formamide: Merck
DETERMINATION OF DEAD TIME
- Method: by using a "dead time marker"
MOBILE PHASES
- Type: 30/70 (v/v) methanol / Milli-Q water
- Experiments with additives carried out on separate columns: no
- Solutes for dissolving test and reference substances: methanol
REFERENCE SUBSTANCES
- Identity: Phenol, Methylbenzoate, Naphtalene, Mercaptodimethur, Fenthion and Phenantrene.
REPETITIONS
- Number of determinations: 2 - Key result
- Type:
- log Koc
- Value:
- 2.47 dimensionless
- Temp.:
- 35 °C
- Key result
- Type:
- Koc
- Value:
- 292 L/kg
- Temp.:
- 35 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the item was found to be log Koc = 2.47 at 35 °C. The Koc was 292 L/kg at 35 °C.
- Executive summary:
A study according to OECD 117 and OECD 121 was performed to determine the adsorption coefficient log Koc of the test item. The HPLC method was used. A series of reference substance, in accordance with OECD 121, was used as the calibration series for the HPLC measurements. Two series were injected. The series included the reference substances and the test item. The test item was injected in-between the series of the reference substances. The dead time to was determined by measuring the retention time of a dead time marker – Formamide. The dead time marker was dissolved in methanol and was diluted by a factor 10 with 30:70 % (v/v) methanol/Milli-Q water and injected as single standard twice. The reference substances were dissolved in methanol at concentrations between 1 and 2 g/L with the mobile phase methanol/Milli-Q water 30:70 % (v/v) and injected as standard twice. A 2.09 g/L stock solution of the test item was prepared in acetonitrile, diluted by a factor of 100 with 30:70 % (v/v) methanol/Milli-Q water and injected twice. A 1% solution of acetonitrile in 30:70 % (v/v) methanol/Milli-Q water was used as blank. The chromatograms were recorded for 45 minutes. The adsorption coefficient of the item was found to be log Koc = 2.47 at 35 °C. The Koc was 292 L/kg at 35 °C.
Reference
Table 1: Determination of the Dead Time to
Dead time marker | to in min 1st Measurement | to in min 2nd Measurement | to in min Mean |
Formamide | 2.014 | 2.013 | 2.014 |
Dead time: to = 2.014
Table 2: Results of the test
Substance | tr* | K* | Log K* | Log Koc | Koc |
Reference Substance |
|
|
|
|
|
Phenol | 2.95 | 0.466 | -0.331 | 1.32 |
|
Methylbenzoate . | 4.09 | 1.03 | 0.013 | 1.80 |
|
Naphtalene | 7.47 | 2.71 | 0.433 | 2.75 |
|
Mercaptodimethur | 8.15 | 3.05 | 0.484 | 3.10 |
|
Fenthion | 24.1 | 10.98 | 1.041 | 3.31 |
|
Phenantrene | 21.6 | 9.72 | 0.988 | 4.09 |
|
Test substance |
|
|
|
|
|
Peak | 6.09 | 2.03 | 0.306 | 2.47** | 292 |
* Mean value of the retention times of both chromatograms.
** Interpolated from the regression line: y = 0.5012x - 0.9294 (r = 0.9501, n = 6)
Description of key information
The adsorption coefficient of the item was found to be log Koc = 2.47 at 35 °C. The Koc was 292 L/kg at 35 °C.
Key value for chemical safety assessment
- Koc at 20 °C:
- 292
Additional information
A study according to OECD 117 and OECD 121 was performed to determine the adsorption coefficient log Koc of the test item. The HPLC method was used. A series of reference substance, in accordance with OECD 121, was used as the calibration series for the HPLC measurements. Two series were injected. The series included the reference substances and the test item. The test item was injected in-between the series of the reference substances. The dead time to was determined by measuring the retention time of a dead time marker – Formamide. The dead time marker was dissolved in methanol and was diluted by a factor 10 with 30/70 (v/v) methanol/Milli-Q water and injected as single standard twice. The reference substances were dissolved in methanol at concentrations between 1 and 2 g/L with the mobile phase methanol/Milli-Q water 30:70 % (v/v) and injected as standard twice. A 2.09 g/L stock solution of the test item was prepared in acetonitrile, diluted by a factor of 100 with 30:70 % (v/v) methanol/Milli-Q water and injected twice. A 1% solution of acetonitrile in 30:70 % (v/v) methanol/Milli-Q water was used as blank. The chromatograms were recorded for 45 minutes. The adsorption coefficient of the item was found to be log Koc = 2.47 at 35 °C. The Koc was 292 L/kg at 35 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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