Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-460-0 | CAS number: 1471311-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 November 1990 to 16 November 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
- Justification for type of information:
- This study was conducted prior to the introduction of in vitro techniques.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous substances Act (16 CFR 1500)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction product of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and phenol, heptyl derivs.
- EC Number:
- 939-460-0
- Cas Number:
- 1471311-26-8
- Molecular formula:
- Too complex
- IUPAC Name:
- Reaction product of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and phenol, heptyl derivs.
- Test material form:
- liquid: viscous
- Details on test material:
- - Physical state: viscous light brown liquid
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: Young adult
- Housing: wire mesh suspension cages
- Diet (e.g. ad libitum): Purina Laboratory Rabbit Chow, ad libitum
- Water (e.g. ad libitum): tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 13 November 1990 To: 16 November 1990
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): tested as supplied - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24 and 72 hours
- Number of animals:
- 1 male and 1 female
- Details on study design:
- TEST SITE
- Area of exposure: 1 inch by 1 inch
- Type of wrap if used: gauze patch, adhesive tape, rubber dam and outer layer of gauze
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Patch wiped free with water or mineral oil.
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize method
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 48
- Score:
- 5.5
- Max. score:
- 6
- Reversibility:
- no data
Any other information on results incl. tables
Table of Observations
Rabbit Number |
Erythema |
Oedema |
||
24 h |
72 h |
24 h |
72 h |
|
100% |
||||
1 |
3LPCS |
3LPCS |
3 |
3 |
2 |
2SC |
2SC |
3 |
3 |
Mean Total |
2.5 |
3.0 |
L = Light brown discoloration
P = Erythema taken at perimeter
C = Coriaceousness on site
S = Spreading of erythema beyond site
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material is a skin irritant.
- Executive summary:
Test Guidance
Skin irritation study performed by a similar method to Federal Hazardous Substances Act (16 CFR 1500).
Method and Material
Two New Zealand White rabbits were shaved and a 0.5 mL portion of the test material was applied to an intact skin site. A gauze patch was placed over each application site and an impervious material was wrapped around the trunk of the animal to hold the patches. The wrapping was removed after 4 hours and washed .
Treated areas were examined for erythema and oedema using the Draize method of scoring at 24 and 72 hours.
The animals treated were also used simultaneously for the determination of the eye irritation potential of the material; see Key eye irritation Kreuzmann 1990
Results
The neat (100%) test material induced moderate to severe erythema and slight to moderate oedema at 24 and 72 hour observations. Coriaceousness and a light brown discolouration was observed at the application site.
There was no evidence of reversibility over the limited timeframe of the study.
Conclusion
In accordance with EU CLP Regulation (EC) No. 1272/2008, classification of this substance as Category 2 skin irritant is required for skin corrosion/irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.