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EC number: 257-048-2 | CAS number: 51200-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two New Zealand albino rabbits (all male) were treated at each dose level (200 mg/kg, 970 mg/kg, 2000 mg/kg)
The skin of one rabbit from each pair was abraded by light scoring with a scalpel blade. The entire trunk of the rabbit was wrapped with a tight-fitting sleeve constructed of rubber dam material backed by aluminum screening. after 24 hs exposure, test areas were wiped clean with paper towels which were soaked in tepid tap waterAfter 24-hour exposure period, the skin responses were evaluated and the animals were returned to cages and held for a 14 days observation period.
- Necropsy of survivors was performed
- Other examinations performed: clinical signs, body weight - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4,4-dimethyloxazolidine
- EC Number:
- 257-048-2
- EC Name:
- 4,4-dimethyloxazolidine
- Cas Number:
- 51200-87-4
- Molecular formula:
- C5H11NO
- IUPAC Name:
- 4,4-dimethyl-1,3-oxazolidine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Test material name: Oxazolidine-A
- Lot No. of test material: 575916
- Purity: 87.4%
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: not specified; adults
- Weight at study initiation: 2-3 kg
- Housing: Cages, not further specified
ENVIRONMENTAL CONDITIONS
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: skin of the lateral trunk of rabbits from which the hair had been removed by clipping. The skin of one rabbit from each pair was abrader by light scoring with an scalpel blade
- Type of wrap if used: the entire trunk of the rabbit was wrapped with a tight-fitting sleeve constructed of rubber dam material backed by aluminum screening.
REMOVAL OF TEST SUBSTANCE
- Washing: Test areas were wiped clean with paper towels which were soaked in tepid tap water
- Time after start of exposure: 24-hour exposure period
TEST MATERIAL
- Amount(s) applied : animal #1and 2 0.57 ml, animal #3: 2.85 ml, animal #4: 3.24 ml, animal #5: 6.27ml and animal#6: 5.63 ml
- Concentration: undiluted
- Constant volume or concentration used: no, volume was changed according to animal weight
- Duration of exposure:
- 24 hours
- Doses:
- 200 mg/kg, 970 mg/kg, 2000 mg/kg
- No. of animals per sex per dose:
- Two rabbits (all male) were treated at each dose level.
The skin of one rabbit from each pair was abraded by light scoring with a scalpel blade. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: After 24-hour exposure period, the skin responses were evaluated and the animals were returned to cages and held for a 14 days observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 970 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The two animals exposed to 2000 mg/kg died during the 24-hour exposure period.
- Clinical signs:
- other: There was continued and progressive severity of the skin responses during the 2-week observation period. At the time of necropsy, the test areas were covered by thick eschar formation; there was serous or puriform exudate under the eschar. This latter eff
- Gross pathology:
- Aside from the obvious effects on the skin, there were no remarkable findings at necropsy.
- Other findings:
- There were no detectable changes in behaviour
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- estimated LD50 on this experiment 970-2000 mg/kg.
- Conclusions:
- Treatment of rabbits by dermal application of Oxazolidine-A (CAS 51200-87-4) resulted in severe skin responses as determined by erythema or eschar formation and the production of edema. At the highest dose tested, 2000 mg/kg, a systemic effect was produced as was evidenced by the death of both test animals within 24 hours after application of the test material. The estimated LD50 on this experiment was 970-2000 mg/kg.
- Executive summary:
Two New Zealand albino rabbits (all male) were treated at each dose level (200 mg/kg, 970 mg/kg, 2000 mg/kg)
The skin of one rabbit from each pair was abraded by light scoring with a scalpel blade. The entire trunk of the rabbit was wrapped with a tight-fitting sleeve constructed of rubber dam material backed by aluminum screening. after 24 hs exposure, test areas were wiped clean with paper towels which were soaked in tepid tap waterAfter 24-hour exposure period, the skin responses were evaluated and the animals were returned to cages and held for a 14 days observation period.
Necropsy of survivors was performed. Other examinations performed: clinical signs, body weight
Treatment of rabbits by dermal application of Oxazolidine-A (CAS 51200-87-4) resulted in severe skin responses as determined by erythema or eschar formation and the production of edema. At the highest dose tested, 2000 mg/kg, a systemic effect was produced as was evidenced by the death of both test animals within 24 hours after application of the test material. The estimated LD50 on this experiment was 970-2000 mg/kg.
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