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Diss Factsheets
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EC number: 205-766-1 | CAS number: 150-68-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In general, the methods and procedures used were the same as those used in earlier work (Gaines (1960). The acute toxicity of pesticides to rats. Toxicol. Appl. Pharmacol. 2, 88-99 and
Gaines (1969). Acute toxicity of pesticides. Toxicol. Appl. Pharmacol. 14,515-534.) - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Monuron
- EC Number:
- 205-766-1
- EC Name:
- Monuron
- Cas Number:
- 150-68-5
- Molecular formula:
- C9H11ClN2O
- IUPAC Name:
- 1-(4-chlorophenyl)-3,3-dimethylurea
- Test material form:
- not specified
1
- Specific details on test material used for the study:
- technical grade
Test animals
- Species:
- rat
- Strain:
- Sherman
- Remarks:
- adult specific-pathogen-free (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: The rat colony was rederived via cesarean section and maintained under barrier conditions by the U.S. Centers for Disease Control, Atlanta, Georgia. Animals were transferred from the barrier facility at weaning and kept in conventional quarters until used
- Females (if applicable) nulliparous and non-pregnant: [yes/no]
- Age at study initiation: Adult animals were at least 90 days of age when tested.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- propylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: the freshly shaved shoulder and back area
TEST MATERIAL
- Amount(s) applied (volume or weight with unit):Whenever possible the compounds were administered in volumes of 1.6 mL/kg body weight for dermal dosing. Dosage volumes were routinely 1.6-10 mL/kg for dermal dosing.
- Concentration (if solution): Whenever possible the compounds were formulated in varying concentrations.
- No. of animals per sex per dose:
- Minima of 10 animals per group and four dosage levels were used for each LD50 calculation.
- Details on study design:
- - Duration of observation period following administration: The animals were observed for at least 14 days after dosing or until recovered from signs of toxicity.
- Statistics:
- LD50 values and related parameters were calculated using a computer based implementation of Finney’s maximum likelihood probit technique (Lieberman, 1983).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
Any other information on results incl. tables
Table 1. Acute dermal toxicity of Monuron in ratsa
Common name |
Ageb |
Sex |
Route |
LD50 (mg/kg) |
Monuron |
A |
M |
Dermal |
>2500c |
|
A |
F |
Dermal |
>2500c |
|
|
|
|
|
a For dermal dosing, compounds were usually dissolved in xylene.
Dosage volumes were routinely 5-10 mL/kg for oral dosing and 1.6-10 mL/kg for dermal dosing. Exceptions to the above are noted.
b A = Adult; W = Weanling.
c In propyIene glycol suspension.
Applicant's summary and conclusion
- Conclusions:
- Dermal LD50 for monuron was > 2500 mg/kg.
- Executive summary:
LD50 values were determined for 57 pesticides (among which Monuron) administered by the (oral or) dermal route to adult male and female Sherman rats. Many of these and earlier LD50 tests have been done in different years and in various months of the year. Since the LD50 value is influenced by variables such as species, strain, and test method, the best estimates of relative toxicity are derived from data collected in a single species and strain under identical conditions. The values for acute toxicity reported here represent the final compilation of data for the LD50 test program whose purpose was to establish a reliable data base on the relative toxicities of pesticidal chemicals in rats, and to obtain other pertinent information including the type, onset, and duration of toxic effects following a single dose.
Except as indicated the compounds were technical grade and were dissolved or suspended in xylene for dermal application to the freshly shaved shoulder and back area. Monuron was suspended in propylene glycol. Whenever possible the compounds were formulated in varying concentrations and administered in volumes of 1.6 mL/kg body weight for dermal dosing. Because of low toxicity or poor solubility of some of the compounds, it was sometimes necessary to adjust the dose volumes as indicated. Dosage volumes were routinely 1.6-10 mL/kg for dermal dosing.
Adult animals were at least 90 days of age and weanlings were 4-6 weeks of age when tested. Minima of 10 animals per group and four dosage levels were used for each LD50 calculation. The animals were observed for at least 14 days after dosing or until recovered from signs of toxicity. LD50 values and related parameters were calculated using a computer based implementation of Finney’s maximum likelihood probit technique (Lieberman, 1983).
As expected, nearly all of the compounds were substantially less toxic by the dermal route than by the oral route.
For Monuron dermal LD50 was > 2500 mg/kg bw in male and female adult rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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