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Diss Factsheets
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EC number: 203-697-1 | CAS number: 109-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data taken from IUCLID4 report with no information on methods or GLP status.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Characteristics of the General Toxic, Gonadatropic, and Mutagenic Effects of 1,3-chlorobromopropane
- Author:
- Eytingon, A.I.
- Year:
- 1 971
- Bibliographic source:
- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv, No. 12, p. 93-100
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline mentioned in data source.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-bromo-3-chloropropane
- EC Number:
- 203-697-1
- EC Name:
- 1-bromo-3-chloropropane
- Cas Number:
- 109-70-6
- Molecular formula:
- C3H6BrCl
- IUPAC Name:
- 1-bromo-3-chloropropane
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- other: oral and inhalation
- Duration of treatment / exposure:
- 28 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0,045 & 0,0054 mg/liter
- No. of animals per sex per dose:
- 6 animals per group
Examinations
- Observations and examinations performed and frequency:
- Various effects were seen from the high concentration : increased summation threshold index, decreased ability to eliminate sulfobromophthalein from the blood, and increased liver weight coefficients.
- Sacrifice and pathology:
- Histologically, liver changes included moderate albuminoid and fatty degeneration of the parenchyma and focal proliferation of the interstitial tissue cells. Few effects were seen as a result of the lower concentration ; histological effects were mild.
- Other examinations:
- After a one-month recovery period, the residual pathological processes were hardly noticeable, and were of a proliferative nature. Anaphase analysis of bone marrow cells showed higher number of chromosome aberrations in animals exposed to 0,45 mg/liter than in the control animals. Changes in germinal epithelium and a tendency towards reduction in testicular weight coefficient and spermatozoa motility time were noted.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- There were no deaths in animals by the 24th day when animals had received 9 x LD50. During the next 4 days, animals tolerated daily doses nearly as high as the LD50.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- There were no deaths in animals by the 24th day when animals had received 9 x LD50. During the next 4 days, animals tolerated daily doses nearly as high as the LD50.
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- decreased ability to eliminate sulfobromophthalein from the blood
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- increased liver weight coefficients
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- increased summation threshold index
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- liver changes included moderate albuminoid and fatty degeneration of the parenchyma
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- focal proliferation of the interstitial tissue cells.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The observations made on bone marrow cells reavealed chromosome aberrations in animals exposed to 0,45 mg/liter of the test substance : this tends to confirm a mutagenic potential of 1-bromo-3-chloropropane (see abstract in chapter 7.6).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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