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EC number: 279-093-7 | CAS number: 79135-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
not skin irritating
not eye irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
SKIN IRRITATION/CORROSION
The skin irritation test was performed to rabbit skin according to an internal method: a single dose was tested on the skin of six rabbits. 0.5 g of test substance was applied to intact and wound skin of each animal using a 25 cm^2 sticking plaster. The degree of irritation/corrosion was read and scored for oedema and erythema reactions at intervals of 24 and 72 hours. As mean values from 24 to 72 hours consisted of grade 0 erythema and grade 0 oedema, the test substance was found to be not irritant when applied to intact and wound skin of rabbit.
EYE IRRITATION
The substance was tested for eye irritation according to an internal method: a single dose was applied into the eyes of six rabbits. After the exposure for each animal one eye was rinsed and the other one was not rinsed. The degree of eye irritation/corrosion was evaluated by scoring lesions of conjunctiva, cornea, and iris, at specific intervals of 24, 48, 72 hours and 7 days.
Considering the rinsed eye, under this study conditions the substance resulted in no effects on cornea and iris (mean scores 0) except in animal #4 (mean cornea score 0.33) and in animal #3 (mean iris score 0.33). Three animals (#3, #5 and #6) showed no effects on conjunctivae (redness and chemosis mean scores 0). Effects on conjunctivae were observed in the other three animals: redness mean scores were 1.33 and 1 in animal #1 and animals #4 and #2 respectively; chemosis mean scores were 0, 1 and 0.67 in animals #1, #2 and #4 respectively. At the end of the observation period (7 days) all the irritation effects were fully reversible except from conjunctivae redness and chemosis scores that were observed in animal #1 and in animal #4 respectively (grade 1 after 7 days for both effects). Higher scores on cornea, iris and conjunctivae were observed in the unrinsed eye. The reversibility within 7 day-period of these effects was observed in all cases, except from cornea and chemosis (grade 3 and 1 respectively) in animal #4 and redness (grade 1) in animal #5.
Justification for classification or non-classification
SKIN IRRITATION/CORROSION
According to the CLP Regulation (EC 1272/2008) substances that have the potential to induce reversible damage to the skin following the application of a test substance for up to 4 hours are classified in Category 2 (irritating to the skin) if:
-mean value of ≥ 2.3 ≤ 4.0 for erythema/eschar or for oedema in at least 2 of 3 (or 4 out of 6) tested animals from gradings at 24, 48 and 72 h after patch removal or, if reactions are delayed, from grades on 3 consecutive days after the onset of skin reactions; or
-inflammation that persists to the end of the observation period normally 14 d in at least 2 animals, particularly taking into account alopecia (limited area), hyperkeratosis, hyperplasia, and scaling; or
-in some cases where there is pronounced variability of response among animals, with very definite positive effects related to chemical exposure in a single animal but less than the criteria above.
Based on the results of irritation skin study conducted on the test substance, the mean scores (24/48/72h) of erythema and edema were not in the range of ≥ 2.3 - ≤ 4.0; therefore the substance is not classified for skin irritation according to the CLP Regulation (EC 1272/2008).
EYE IRRITATION
According to the CLP Regulation (EC 1272/2008) substances that have the potential to induce reversible eye irritation are classified in Category 2 (irritating to eyes) if, when applied to the eye of an animal, a substance produces at least in 2 of 3 (or 4 out of 6) tested animals, a positive response of:
-corneal opacity ≥ 1 and/or
-iritis ≥ 1, and/or
-conjunctival redness ≥ 2 and/or
-conjunctival oedema (chemosis) ≥ 2,
calculated as the mean scores following grading at 24, 48 and 72 h after installation of the test material, and which fully reverses within an observation period of 21 d.
In the eye irritation test the substance caused some adverse effects: mean values at 24, 48 and 72 h on the unrinsed eye were lower than 2 for conjunctival redness and chemosis scores and lower than 1 for corneal opacity and iris scores in all animals. At the end of the observation period (7 days) all the irritation effects were fully reversible except from conjunctivae redness and chemosis scores that were observed in animal #1 and in animal #4 respectively (grade 1 for both effects). In these both cases, a decreasing trend of observed values occurred during the 7-day study period. This trend was also observed in the worst case for the unrinsed eye of the same two animals. Furthermore, the trend towards lower conjunctival scores was found in all other animals. Therefore, it is reasonable to think that reversibility within 21 days should occur even if at the present study it was not possible to observe the fully reversibility of all the effects within the 7-day study period.
The results show that the substance is not classified for both skin and eye irritation, according to the CLP Regulation (EC n. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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