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Diss Factsheets
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EC number: 916-914-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 13, 2002 to June 21, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Source: A clone of this species was originally supplied by the University of Sheffield/UK in 1992, defined from the supplier as clone 5. Since this date, the clone is bred in the laboratories of RCC.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250.0 mg/L as CaCO3
- Test temperature:
- 20 °C
- Nominal and measured concentrations:
- A water accommodated fraction (WAF) of the test item with a loading rate of 100 mg/L.
- Details on test conditions:
- - Test volume: 50 mL
- Aeration: None
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Photoperiod: 16-hr light: 8-hr dark - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- According to EU Method C.2 and OECD 202 test method, the 48-hr EC0 of TK 12871 (TINUVIN 109) was at least at the loading rates of 100 mg/L.
- Executive summary:
This test using the procedures outlined in the RCC Study Plan for 841658, EU Method C.2 (1992) and OECD 202 (OECD, 1984). The results of this test for TK 12871 (TINUVIN 109) show that all validity criteria were met. All results are based on the loading rate of the test item of 100 mg/L. The 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours) and the 48-hour EC0 of TK 12871 (TINUVIN 109) to Daphnia magna were determined to be at least at the loading rate of 100 mg/L. The 48-hour NOEC and the 48-hour EC0 might even be higher but loading rates in excess of 100 mg/L were not tested. The 48-hour EC50 and the 48-hour EC100 were clearly higher than the loading rate of 100 mg/L. These values could not be quantified since the test item had no toxic effect on the daphnids up to the highest test item concentration which could be dissolved in the test water under the conditions of the test.
Reference
Table 1. Influence of TK 12871 (TINUVIN 109) on the mobility of Daphnia magna
Loading rate (mg/L) |
No. of daphnids tested |
Immobilized daphnids after 24 hours |
Immobilized daphnids after 48 hours |
||
No. |
% |
No. |
% |
||
Control |
20 |
2 |
10* |
2 |
10* |
100 |
20 |
0 |
0 |
0 |
0 |
* An immobilization rate of 10% is tolerated by the test guidelines.
Table 2. Appearance of the test medium during the test period
Loading rate (mg/L) |
Exposure time |
||
0 hours |
24 hours |
48 hours |
|
100 |
0 |
0 |
0 |
Abbreviations:
0: no remarkable observations, clear test medium
1: homogeneous dispersion in the water, turbidity observable
2: noticeable turbidity caused by the test item
3: noticeable coloration caused by the test item
4: Inhomogeneous dispersion of the test item
5: precipitation of the test item
6: test item at the surface
7: test item lying at the bottom of the test beaker
Table 3. Dissolved oxygen concentrations, pH values and temperature in the test medium and the control
Loading rate (mg/L) |
Start (0 hours) |
End (48 hours) |
||||
pH |
Oxygen (mg/L) |
Temperature (°C) |
pH |
Oxygen (mg/L) |
Temperature (°C) |
|
Control |
8.0 |
8.7 |
20 |
7.7 |
8.9 |
20 |
100 |
7.9 |
8.5 |
20 |
7.8 |
8.7 |
20 |
Description of key information
The 48-hr EC0 of TK 12871 (TINUVIN 109) was at least at the loading rates of 100 mg/L for Daphnia magna (OECD TG202, EU Method C.2).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
In limit test, not more than 10 % of the Daphnia were immobilised in the control and the dissolved oxygen concentration of control and test groups at the end of the test was ≥3 mg O2/L. All test validity criteria were met.The pH of the test solutions was within the ranges outlined in the OECD 202 test guideline. All results are based on the loading rate of the test item of 100 mg/L. The 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours) and the 48-hour EC0 of TK 12871 (TINUVIN 109) to Daphnia magna were determined to be at least at the loading rate of 100 mg/L. The 48-hour NOEC and the 48-hour EC0 might even be higher but loading rates in excess of 100 mg/L were not tested. The 48-hour EC50 and the 48-hour EC100 were clearly higher than the loading rate of 100 mg/L. These values could not be quantified since the test item had no toxic effect on the daphnids up to the highest test item concentration which could be dissolved in the test water under the conditions of the test.
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