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EC number: 240-979-3 | CAS number: 16921-30-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to OECD guidelines. However, only four bacterial strains were tested (TA 1535 omitted).
Data source
Reference
- Reference Type:
- publication
- Title:
- Cyto- and genotoxic effects of coordination complexes of platinum, palladium and rhodium in vitro
- Author:
- Bunger J. et al.
- Year:
- 1 996
- Bibliographic source:
- International Archives of Environmental Health, 69, 33-38
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Revised test protocol of Maron and Ames (1983)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- The study differred principally from OECD TG471 in that only four bacterial strains were tested. The recommended strain TA1535 was ommitted.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Potassium hexachloroplatinate (IV)
- IUPAC Name:
- Potassium hexachloroplatinate (IV)
- Reference substance name:
- Dipotassium hexachloroplatinate
- EC Number:
- 240-979-3
- EC Name:
- Dipotassium hexachloroplatinate
- Cas Number:
- 16921-30-5
- Molecular formula:
- Cl6Pt.2K
- IUPAC Name:
- dipotassium hexachloroplatinate(2-)
Constituent 1
Constituent 2
Method
- Target gene:
- Histidine operon
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97a, TA98, TA100 and TA102
- Metabolic activation:
- with and without
- Metabolic activation system:
- Sprague-Dawley rat liver, Induced with phenobarbital and beta-naphthoflavone
- Test concentrations with justification for top dose:
- The test substance was dissolved in distilled water and diluted to 5-500 ug/plate [or possibly 10, 50, 100 or 500 ug/plate] in all four tester strains, in the absence or presence of (4% and 10%) S9. The number of revertant colonies on the plates were recorded after 48 hours of incubation in the dark at 37degC.
Controlsopen allclose all
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Distilled water
- Positive controls:
- yes
- Positive control substance:
- methylmethanesulfonate
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminofluorene
- Details on test system and experimental conditions:
- Tests were done in duplicate at least three times.
- Evaluation criteria:
- For the test substance to be considered mutagenic, a two-fold (or more) increase in the mean revertant numbers must be observed in the plates containing the test substanced compared to the spontaneous reversion rate.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium, other: TA97a, TA98, TA100 and TA102
- Metabolic activation:
- with
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Species / strain:
- S. typhimurium, other: TA98, TA100 and TA102
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Species / strain:
- S. typhimurium, other: TA97a
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Additional information on results:
- The test substance caused a 2- to greater than 10-fold increase in revertants in all four tester strains (compared with spontaneous reversion rates), in the presence of S9. In the absence of S9, a 2- to 10-fold increase in reversion rates was seen in three tester strains, whereas in TA97a no mutagenic effect was evident. "The increase in reverse mutation rates in the samples that tested positive was dosage-dependent",
Any other information on results incl. tables
High doses of the metal compounds proved toxic to the tester strains", resulting in a thinning of the background bacterial lawn. Although no actual data provided for potassium hexachloroplatinate, the minimum toxic dose for the platinum salts was apparently 100 ug/plate.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive
Dipotassium hexachloroplatinate was mutagenic in a bacterial reverse mutation (Ames) assay using four Salmonella typhimurium strains (TA97a, TA98, TA100 and TA102) when tested in the presence and absence of a rat liver metabolic activation (S9) system. - Executive summary:
Dipotassium hexachloroplatinate was assessed for mutagenic activity in a bacterial reverse mutation (Ames) assay, similar to OECD Test Guideline 471, using Salmonella typhimurium strains TA97a, TA98, TA100 and TA102 and tested at up to 500 μg/plate in both the presence and absence of a metabolic activation system (S9) derived from phenobarbital and beta-naphthoflavone induced rat livers.
Mutagenic effects were seen in all four strains in the presence of metabolic activation and in all but strain TA97a in its absence. Although no cytotoxicity data were provided for the test material, the minimum toxic dose for the platinum salts was apparently 100 μg/plate.
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