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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-710-6 | CAS number: 10325-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: Review
- Adequacy of study:
- weight of evidence
- Reliability:
- other: Not applicable
- Rationale for reliability incl. deficiencies:
- other: Review of existing genotoxicity data on cadmium and cadmium compounds by Prof. Parry, SAFECHEM Independent Consultants in Genetic and Molecular Toxicology, UK
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- A review of the genotoxicity of cadmium compounds
- Author:
- Parry JM and Parry EM
- Year:
- 2 009
- Bibliographic source:
- Review conducted for the International Zinc Association
Materials and methods
- Type of study / information:
- Review of existing studies on in vitro and in vivo genotoxicity of cadmium
- Principles of method if other than guideline:
- Not applicable
Test material
- Reference substance name:
- Cadmium nitrate
- EC Number:
- 233-710-6
- EC Name:
- Cadmium nitrate
- Cas Number:
- 10325-94-7
- Molecular formula:
- Cd(NO3)2
- IUPAC Name:
- cadmium(2+) dinitrate
- Details on test material:
- Not applicable
Constituent 1
Results and discussion
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Cadmium compounds have been shown to induce genetic changes both in vitro and in vivo. There is considerable evidence to suggest that that the primary mechanism of genotoxicity is based upon the production of oxidative lesions.On the assumption of an oxidative mechanism for the genotoxicity of cadmium compounds we can predict that there may be thresholds of genotoxicity at low doses where DNA repair enzymes remove lesions thus reducing the potential for genetic changes in cells and animals.
However, there are some studies which indicate that cadmium compounds inhibit repair activity which may limit activity within potential thresholded regions of the dose response curve. - Executive summary:
Cadmium compounds have been shown to induce genetic changes both in vitro and in vivo. There is considerable evidence to suggest that that the primary mechanism of genotoxicity is based upon the production of oxidative lesions.On the assumption of an oxidative mechanism for the genotoxicity of cadmium compounds we can predict that there may be thresholds of genotoxicity at low doses where DNA repair enzymes remove lesions thus reducing the potential for genetic changes in cells and animals.
However, there are some studies which indicate that cadmium compounds inhibit repair activity which may limit activity within potential thresholded regions of the dose response curve.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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