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Diss Factsheets
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EC number: 203-998-8 | CAS number: 112-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity to the rat
- Author:
- SCALA et al.
- Year:
- 1 973
- Bibliographic source:
- American Industrial Hygiene Association Journal
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- Acute Dermal toxicity of test chemical in rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tridecan-1-ol
- EC Number:
- 203-998-8
- EC Name:
- Tridecan-1-ol
- Cas Number:
- 112-70-9
- Molecular formula:
- C13H28O
- IUPAC Name:
- tridecan-1-ol
- Details on test material:
- - IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Housing: The animals were housed individually
Diet (e.g. ad libitum):ad libitum
Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: the closely clipped, intact abdominal skin
- Type of wrap if used: The exposed area was covered with an occlusive binding of dental damming
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin.
- Time after start of exposure:24 hour - Duration of exposure:
- 24 hours
- Doses:
- 0.10, 0.316, 1.00, and 3.16 ml/kg were administered volumetrically.
- No. of animals per sex per dose:
- groups of 4 (sex not mentioned)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Observations for signs of toxicity were made frequently on the day of application and once daily afterward for a total of 7 days.
Necropsy of survivors performed: yes/no: Yes, Gross necropsies were performed at the end of the experiments. - Statistics:
- The results have been converted to gravimetric expressions by use of the specific gravity.
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Dose reported is the highest dose tested
- Mortality:
- No Mortality observed at 2600 mg/kg bw.
- Clinical signs:
- other: No signs of toxicity observed
- Gross pathology:
- No data
- Other findings:
- On observation of the binders after 24 hours of skin contact, percutaneous absorption was evident with all the alcohols even though the median lethal dose was not achieved.
Any other information on results incl. tables
Table: Acute dermal toxicity of alcohols
Alcohol |
LD50 (gm/kg) |
Signs |
Tridecyl |
>2.6 |
None |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- Acute dermal toxicity dose (LD50) was considered to be >2600 mg/kg bw, when groups of 4 albino rabbits were treated with test chemical by dermal application occlusively to the closely clipped, intact abdominal skin for 24 hours.
- Executive summary:
Acute dermal toxicity study was conducted by using test chemical in groups of 4 albino rabbits at the dose concentration of 0.10, 0.316, 1.00, and 3.16 ml/kg bw administered volumetrically. The animals were housed individually with feed and water freely available. No mechanical restraints were used.The test chemical was applied full-strength to the closely clipped, intact abdominal skin of albino rabbits. The exposed area was covered with an occlusive binding of dental damming for 24 hours. After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin. Observations for signs of toxicity were made frequently on the day of application and once daily afterward for a total of 7 days. Gross necropsies were performed at the end of the experiments. The results have been converted to gravimetric expressions by use of the specific gravity. No Mortality observed at 2600 mg/kg bw. No signs of toxicity observed. On observation of the binders after 24 hours of skin contact, percutaneous absorption was evident with the chemical even though the median lethal dose was not achieved. Therefore, LD50 was considered to be >2600 mg/kg bw, when groups of 4 albino rabbits were treated with test chemical by dermal application occlusively to the closely clipped, intact abdominal skin for 24 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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