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Diss Factsheets
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EC number: 202-858-3 | CAS number: 100-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- other: microfiche
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
- Principles of method if other than guideline:
- other: subacute inhalation study (9 day vapour inhalation toxicity study)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 202-858-3
- EC Name:
- Cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 100-50-5
- Molecular formula:
- C7H10O
- IUPAC Name:
- cyclohex-3-ene-1-carbaldehyde
- Details on test material:
- tetrahydrobenzaldehyde (THBA), purity: 99.6%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Duration of treatment / exposure:
- 6 hours/day for 5 consecutive days, after 2 days without exposure, the animals were exposed for additional 4 consecutive days
- Frequency of treatment:
- 6 hours/day for 5 consecutive days, after 2 days without exposure, the animals were exposed for additional 4 consecutive days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 75, 250, 500 ppm
Basis:
- No. of animals per sex per dose:
- 10 animals per sex and dose, in addition: control and 500 ppmgroups: 5 animals per sex for the 4-week recovery period
- Control animals:
- yes, sham-exposed
Results and discussion
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 75 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: decrease in body weight gain, minimal to mild epithelial hyperplasia/dysplasia of tissues from the nasal mucosa
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Mean THBA concentrations were 77.4 (+/- 6.0), 244 (+/- 18.8), and 479 (+/- 38.2) ppm. There were no mortalities prior to the scheduled sacrifices.
Urine staining and periocular swelling were observed in animals from the 500 ppm exposure group during the exposure regime and during the recovery period. On study day 12, body weight was decreased for the male and female animals from the 500 ppm exposure group. Body weight gain was decreased for male and female animals from all exposure groups during the first week of the exposure regime. During the second week of the exposure regime, the body weight gain was decreased for the males from 250 and 500 ppm exposure groups. Also, during the second week of exposure regime, female animals had decreased body weight gain, except those from the 250 ppm exposure group on Day 8. During the recovery period, the female animals from the 500 ppm exposure group had decreased body weight gain until the fourth week of recovery. For the first week of the exposure regimen, male animals from the 250 and 500 ppm exposure groups had decreased food consumption values. Also, for the first week, the female animals from the 75, 250, and 500 ppm exposure groups had decreased food consumption values. For the second week, female animals from the 500 ppm exposure group still had decreased food consumption values.
Clinical pathologic findings at the end of the exposure regime included decreased platelet counts for male animals from the 250 and 500 ppm exposure groups and for female animals from the 500 ppm exposure group. At the end of the recovery period, the platelet counts were not decreased. After the exposure regime, total urine volumes were decreased for the male and female animals from the 250 and 500 ppm exposure groups. Male animals from the 250 and 500 ppm exposure groups and female animals from the 500 ppm exposure group had increased urine osmolality. Male and female animals from the 500 ppm exposure group had decreased urine pH and increased frequency of higher ketone concentrations. At the recovery period sacrifice, these values were not different from control values.
At the end of the exposure regimen, urine staining of the urogenital region and swelling of the periocular tissues were observed for both sexes of animals from the 500 ppm exposure group. These findings were resolved upon recovery. In the male and female animals from the 250 and 500 ppm exposure groups, mild to moderate injury to the tissues of the nasal mucosa was observed, as evidenced by rhinitis, epithelial necrosis, and a varity of degenerative and/or regenerative lesions of the epithelium including vacuolization, hyperplasia, dysplasia, and squamous metaplasia. Minimal or mild epithelial hyperplasia/dysplasia was found in some animals from the 75 ppm group, which was probably related to THBA exposure. Male animals were slightly more affected than female animals. At the recovery period sacrifice, most of the lesions were resolved.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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