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Diss Factsheets
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EC number: 212-449-1 | CAS number: 818-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic bioaccumulation
This study was waived on the basis that it was not technically feasible to conduct.
Following decision number CCH-D-0000003196-74-05/F, it was attempted to conduct the bioaccumulation in aquatic species study (OECD 305) required under point 9.3.2. of Annex IX of Regulation (EC) No. 1907/2006. It was determined however that it is not technically feasible to conduct this study, due to the inability to develop a substance specific analytical method that could be used to monitor the substance during the performance of the test.
A literature search was conducted in order to determine the available data on the registered substance. No appropriate data that was judged to be both reliable and relevant to the material itself was uncovered.
The following information is taken into account for any hazard / risk / bioaccumulation assessment:
DBTO can be considered to have low solubility in water and octanol. Although it was not technically feasible to determine a partition coefficient, the visual assessment of solubility in both water and n-octanol was found to be less than 1 mg/L.
In the OECD SIDS report for Dibutyltin oxide (5.12.2008) BCFWIN v2.15 (EPI Suite, US EPA 2000) was used to estimate a BCF value of 63720 L/kg. However in the report it is emphasised that this result should be used with caution as the model was not validated for chemicals that contain metals in their molecular structure.
In addition, a recalculation with BCFBAF v3.01 (EPI Suite, US EPA 2011), the updated program of BCFWIN, was performed and a BCF of 38360 L/kg wwt (based on the regression method) and a BCF of 574 for the upper trophic level (based on Arnot-Gobas method) were estimated. However once again, EPI Suite clearly states that inorganic and organometallic chemicals generally are outside the domain.
The program estimates the BCF of an organic compound using the log octanol-water partition coefficient (Kow). However, the Log Kow has also been estimated using EPI Suite, which as stated above is not validated for this type of compound. The BCF estimate for this compound is therefore calculated from a QSAR which is itself based on a value determined using a QSAR. In both instances, the QSARs used are not validated for this type of compound and the reliability of this estimation is highly questionable.
In the absence of any experimental data for DBTO, it is possible to refer to data on the similar compound DBTC. This reference is considered appropriate as the species of concern with regard to bioaccumulation will be the DBT moiety. In a BCF study with either compound, analysis would be for the same species (the DBT moiety or total tin).
In aquatic bioaccumulation studies DBTC had BCFs of 5 to 135. These are significantly below 2000.
The available data are adequate for classification and labelling purposes and PBT assessment, so no further testing is required. Also direct and indirect exposure of the aquatic compartment is unlikely.
Terrestrial bioaccumulation
No data is available. However, based on the low BCFs derived from the fish bioaccumulation study with the structurally similar substance DBTC above, there is considered to be a low risk of bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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