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EC number: 204-886-1 | CAS number: 128-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental study performed using standard test guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical was performed on Rats(Male/female)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- EC Number:
- 204-886-1
- EC Name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- Cas Number:
- 128-44-9
- Molecular formula:
- C7H5NO3S.Na
- IUPAC Name:
- sodium 1,1,3-trioxo-2,3-dihydro-1H-1λ⁶,2-benzothiazol-2-ide
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- Test animals :Spraque-Dawley rats (male/female), SPF breed : WIGA, Sulzfeld, FR G
Body weight : 77/13 0
Mean weight for
- male animals : 298 g
- female animals : 215 g
Diet : The animals were offered Herilan MRH-Kraftfutter, supplied by H . EGGERSMANN, Rinteln/Weser, FRG, and water ad libitum . Diet withdrawn 16 hours before beginning of study .
Form of application : The product was administered once by gavage as a 50% solution in aqua dest . in doses of 5620, 6810, 8250 and 10000 mg/kg .
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details available
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- the product was administered once by gavage as a 50% solution in aqua dest . in doses of 5620, 6810, 8250 and 10000 mg/kg .
- Doses:
- 5620 mg/kg
6810 mg/kg
8250 mg/kg
and 10000 mg/kg - No. of animals per sex per dose:
- 10 males
10 female - Control animals:
- not specified
- Details on study design:
- Not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8 980 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no other details available
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 9 140 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no other details available
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 8 820 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no other details available
- Mortality:
- 50% death was observed in male and female rats
- Clinical signs:
- other: Not specified
- Gross pathology:
- Not specified
- Other findings:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral median lethal dose (LD50) of test chemical in male/female sprague-dawley rat was determined to be 8440-9710 mg/kg of body weight. LD50 value indicates that the test chemical does not exhibits acute toxicity by the oral route.
- Executive summary:
The acute oral toxicity of test chemical was performed in Sprague-Dawley rats . For this purpose, the product was administered once by gavage as a 50% solution in aqua dest . in doses of 5620, 6810, 8250 and 10000 mg/kg .
The median lethal dose (LD 50) after 14 days was observed to be 8980 (8440 - 9710) mg/kg in male and female rats.In male animals LD50 value was observed to be 9140 (8350 - 10510) mg/kg whereas in female animals ,8820 (7960 - 10090) mg/kg.
From the above study it is concluded that test chemical does not exhibits acute toxicity by the oral route.
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