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Diss Factsheets
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EC number: 205-739-4 | CAS number: 149-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2008 - March 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study; the study was conducted on the basis of the official method as defined in the O.E.C.D. guideline N° 423 dated December 17'h, 200 land the test method B.I tris of the Directive N° 2004173/EC.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium hydroxymethanesulphinate
- EC Number:
- 205-739-4
- EC Name:
- Sodium hydroxymethanesulphinate
- Cas Number:
- 149-44-0
- Molecular formula:
- CH4O3S.Na
- IUPAC Name:
- sodium hydroxymethanesulphinate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Elevage JANVIER (53940 Le Genest St lsle - France)
- Age at study initiation: 8 weeks
- Weight at study initiation: 189-208 g
- Fasting period before study: food was removed at day 1 and then redistributed 4 hours after the test item administration.
- Housing: Three healthy female rats were kept in solid-bottomed cJear polycarbonate cages with a stainless steel mesh lid. Each cage contains sawdust bedding which was changed at least 2 times a week.
- Diet (e.g. ad libitum): M20-rat/mouse maintenance (Speciel Diets Service)
- Water (e.g. ad libitum): tap-water from public distribution system
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): between 20°C and 22°C
- Humidity (%): between 36% and 57%
- Air changes (per hr): conventional air conditioning
- Photoperiod (hrs dark / hrs light): lighting time: 12 hours daily
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2000 mg/kg bw.
- Amount of vehicle (if gavage): 10 mL/kg bw. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 female rats were treated
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
1. Daily examination: systematic examinations were carried out to identify any behavioural or toxic effects on the major physiological functions 14 days after administration of the test item. This examination focuses particularly on a list of symptoms, recorded as "present" or "absent" on the observation sheet. Observations and a mortality report were then carried out every day for 14 days.
2. Periodical examinations: the animals were weighed on day 0 (D0)(just before administering the test item) then on D2, D7, and D14. Weight changes were calculated and recorded.
3. Examination at the end of the test: on D14, the animals were anaesthetised with sodiun pentobarbital and administration continued to
fatal levels. Macroscopic observations were entered on individual autopsy sheets. Only those organs likely to be modified in cases of aeute toxicity were examined. Those presenting macroscopic anomalies can be removed and preserved in view to microscopic exanimations.
- Necropsy of survivors performed: yes - Statistics:
- no data given in the test report
Results and discussion
- Preliminary study:
- no preliminary study was conducted
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No clinical signs related to the administration of the test item were observed.
- Gross pathology:
- The macroscopical examination of the animals at the end of the study did not reveal treatment-related changes.
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test item is > 5,000 mg/kg body weight by oral route in the rat
- Executive summary:
The test item was administered by oral route to a group of 6 female Sprague Dawley rats at the single dose of 2,000 mg/kg body weight.
No mortality occurred during the study.
No clinical signs related to the administration of the test item were observed.
The body weight evolution of the animals remained normal throughout the study.
The macroscopical examination of the animals at the end of the study did not reveal treatment-related changes.
In conclusion, the LD50of the test item is > 5,000 mg/kg body weight by oral route in the rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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