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EC number: 629-705-7 | CAS number: 1228186-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
As for aquatic compartment, no tests on terrestrial species are available for N-benzyl-N-C16-18 (even numbered)-alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride. Nevertheless analogy can be made with N-C16-C18(even numbered)-alkyl-N,N-dimethyl-C16-C18(even numbered)-alkyl-1-aminium chloride (DHTDMAC) as the only one difference between the 2 substances is the presence/absence of benzyl group which is not supposed to impact toxicity potential. The expected no difference between the 2 substances about toxicity potential is also supported by acute ecotoxicity data generated confirming the same range of environmental toxicity.
Therefore, for covering missing information about terrestrial species toxicity, data are read-acrossed from DHTDMAC (for which a European Risk Assessment Report (RAR) prepared by German Authorities and published in 2002 is available) which are considered as suitable for covering
N-benzyl-N-C16-18 (even numbered)-alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride terrestrial toxicity.
The effect values are all nominal values and are not converted to a standard soil of a defined organic carbon content, because this does not seem to be adequate as the bioavailability of DODMAC/DHTDMAC is not determined by the organic matter content alone but also by other soil parameters e.g. ionic binding. The different test concentrations were prepared at maximum one day before the start of the test and adsorption was rapid.
Toxicity of DHTDMAC to terrestrial organisms
Species |
Endpoint |
Effect Conc. |
Substance |
Reference |
Sinapis alba Triticum aestivum Linum utisatissimum |
14d EC5 14d EC50 14d EC5 14d EC5 |
1,400 mg/kg 3,540 mg/kg > 1,000 mg/kg > 1000 mg/kg |
DHTDMAC |
Pestemer et al., 1991 |
Sorghum bicolor Helianthus annuus |
28d EC50 NOEC 28d EC50 NOEC |
2,530 mg/kg 1,000 mg/kg 2,930 mg/kg 1,000 mg/kg |
DHTDMAC |
Windeatt, 1987 |
Avena sativa Brassica rapa |
14d NOEC 14d NOEC |
> 1,000 mg/kg > 1,000 mg/kg |
DHTDMAC |
Stanley & Tapp, 1982 |
Eisenia fetida |
14d NOEC |
> 1,000 mg/kg |
DHTDMAC |
Coulson et al., 1989 |
Lycopersicum escul. Lactuca sativa Hordeum vulgare |
NOEC (growth) |
> 40 g/kg (dw) |
DHTDMAC |
Topping & Waters, cited in ECETOC 1993 |
soil microorganisms |
14w NOEC 28d NOEC |
> 400 mg/kg > 365 mg/kg |
DHTDMAC DHTDMAC |
Procter & Gamble, 1992 Täuber et al., 1986 |
The toxicity of DHTDMAC (75% purity; named DSDMAC in the reference) to plant seedlings was tested by Pestemer et al. (Pestemer et al. (1991). Einfluß von Tensiden auf Pflanzenwachstum und Schadstoffverfügbarkeit im Boden, UBA Texte 8/91) in a loamy sandy soil (1.3% organic carbon, 9.9% clay, 54.3 sand, 35.7 silt). Seedlings with developed cotyledons were exposed for 14 days. Related to fresh weight reduction the most sensitive species was Sinapis alba with an EC5 of 1,400 mg/kg dry weight and an EC50 of 3,540 mg/kg dry weight. For Triticum aestivum and Linum utisatissimum the EC5-values were above 1,000 mg/kg dw. In a germination test DHTDMAC concentrations up to 3.2 g/l had no inhibiting effect on Lepidium sativum (Pestemer et al. 1991).
In another study (Windeatt (1987). Effect on growth of Sorghumn bicolor, Helianthus annuus and Phaseolus aureus, internal report
no. BL/B/3181) the influence of DHTDMAC (76.1% active ingredient = quartenary ammonium) on the emergence of plant seedlings and the early growth stages of Sorghum bicolor and Helianthus annuus were investigated. Potting compost with about 80% sand/gravel and 20% silt/clay including 4% organic matter was used as substrate. The highest test concentration of 10 g active ingredient of DHTDMAC per kg dry soil had no significant effect on the emergence of seeds after 7 days. After further 21 days the EC50 for fresh weight reduction of the seedlings was 2530 mg/kg for Sorghum bicolor and 2,930 mg/kg for Helianthus annuus (active ingredient in dry soil). 1,000 mg/kg was the highest test concentration with no growth effect. For Phaseolus aureus the 28 d EC50 was > 10 g/kg.
Similar results were reported for Avena sativa and Brassica rapa (Stanley, Tapp (1982). An assessment of ecotoxicological test methods: Part VIII. The effectc of nine chemicals on the growth of Avena sativa and Brassica rapa, ICI Internal Report BL/A/2164; cited in: ECETOC (1993)). Plant seedlings exposed after germination for 14 days showed no reduction of growth at 1,000 mg DHTDMAC/kg dry soil (OECD draft guideline, 1981, no further details available).
Eisenia fetida was exposed to DHTDMAC (solved in methanol, 76.1% active ingredient) incorporated into artificial soil consisting of 9.4% organic matter, 70% fine sand and 20% kaolinite clay (Coulson et al. (1989). Determination of toxicity to the earthworm Eisenia fetida, internal report no. BL/B/3559.). At the only concentration of the definitive test with 1,000 mg active ingredient/kg dry soil no mortality, no significant reduction in body weight nor any behavioral effects were observed after 14 days.
Concerning the toxicity of DHTDMAC to soil microorganisms two studies are cited in the ECETOC report (1993) for which no test protocols are availble. However, they can give a rough indication on possible effects. Soil respiration was measured with soil samples amended with 12.3 g activated sludge and 365 mg DHTDMAC per kg standard soil (Täuber et al. (1986). Environmental aspects of cationic fabric softeners, poster cited in ECETOC (1993)). After 28 days no depression of oxygen uptake could be measured. In a study of Procter & Gamble (Procter & Gamble (1992). unpublished study, cited in ECETOC 1993) two different soils containing 400 mg DHTDMAC/kg produced 96 and 119% carbon dioxide compared to the controls over 14 weeks.
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