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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-453-1 | CAS number: 95-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 5.9 mg/kg bw/day
Justification for classification or non-classification
Classification according to Annex I of the directive 67/548/EEC - 26. ATP
Category 2 carcinogen
R45 May cause cancer.
By CLP as Carc Cat 1B May cause cancer.
Additional information
For 2,4-TDA valid long-term feeding studies in rats and mice are available similar to OECD TG 451.
Oral intake to rats at doses of 5.9 mg/kg bw/day 2,4-TDA and more over a period of up to 103 weeks lead to a dose dependent increase of hepatocellular carcinomas or neoplastic nodules in both sexes. In addition, 2,4-TDA induced adenomas and carcinomas of the mammary gland in females as well as fibromas of the subcutaneous tissue and an increased incidence of lung tumors (although statistically not significant) in males (NCI 1979, Cardy 1979, Sontag 1981, Ito et al. 1969, Stula and Aftosmis 1976). In mice hepatocellular carcinomas occurred significant in females after oral application of doses of 15 and 30 mg/kg bw/day for 101 weeks. In addition, oral long-life administration of 2,4-TDA may have increased the incidence of lymphomas in female mice. Neoplasms of the lung seen as adenomas and/or adenocarcinomas, and of the hematopoietic system were slightly increased in male mice. But no tumors occurred at significantly increased incidences in male mice (NCI 1979, Reuber 1979).
In summary, 2,4-TDA was carcinogenic in rats and mice after oral long-term administration.
Carcinogenicity: via oral route (target organ): cardiovascular / hematological: hematopoiesis; digestive: liver; glandular: mammary gland; respiratory: lung; other: skin
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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