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Diss Factsheets
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EC number: 256-905-8 | CAS number: 51000-52-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a GLP or O.E.C.D. Testing Guideline Study, no details on the study design or rationales for the selection of the doses.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
- Principles of method if other than guideline:
- Standard acute dermal exposure practice.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Vinyl neodecanoate
- EC Number:
- 256-905-8
- EC Name:
- Vinyl neodecanoate
- Cas Number:
- 51000-52-3
- Molecular formula:
- C12H22O2
- IUPAC Name:
- vinyl neodecanoate
- Details on test material:
- As per Vinyl Neodeconoate IUCLID 4 Data Set
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were 12 - 13 weeks of age when placed on-study.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The 24 h LD50 in male and female Wistar rats was determined by method of Noaks and Sanderson (1969). Two groups of rats (two males and two females/group) age 12-13 weeks, were used in this test. Vinyl neodecanoate (2 and 4 ml/kg per group) was placed on the shaved dorso-lumbar skin and was kept in contact with skin by impermeable dressings of aluminum foil and water proof plaster. The dressing was removed after 24 hr and the exposed skin was washed with diluted detergent solution and then rats were watched for signs of toxicity during 9 days.
- Duration of exposure:
- 24 hr
- Doses:
- 2.0 and 4.0 ml/kg of body weight
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- Two groups of rats (two males and two females/group) age 12-13 weeks, were used in this test. Vinyl neodecanoate (2 and 4 ml/kg per group) was placed on the shaved dorso-lumbar skin and was kept in contact with skin by impermeable dressings of aluminum foil and water proof plaster. The dressing was removed after 24 hr and the exposed skin was washed with diluted detergent solution and then rats were watched for signs of toxicity during 9 days.
- Statistics:
- No data
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 4 mL/kg bw
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- No data
- Other findings:
- None
Any other information on results incl. tables
The application of vinyl neodecanoate under occlusive conditions at doses of 2 and 4 ml/kg to skin of rats for 24 hr did not produce any mortality or signs of toxicity. Thus the acute percutaneous (LD50) was estimated to be greater than 4 ml/kg, or > 3540 mg/kg bw when correcting for density (0.885 g/ml).
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- Vinyl Neodeconate was not acutely toxic to rats following 24 hours of occlusive dermal exposure to a dose of > 3.5 grams/Kg of body weight.
- Executive summary:
Two groups of rats (two males and two females/group) were dermally exposed to Vinyl neodecanoate (2 and 4 ml/kg per group) under occlusion for 24 hr. The obsrvation period was 9 days. The application of vinyl neodecanoate at doses of 2 and 4 ml/kg to skin of rat for 24 hr did not produce any mortality or clinical signs toxicity. Thus the acute dermal LD50 was estimated to be greater than 3540 mg/kg of body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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