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EC number: 213-195-4 | CAS number: 929-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Acute Toxicity:
- LD50 (oral, rat) = 3400kg/kg bw (BASF, 1969)
- LC50 (inhalation, rat) > 8,7 mg/m3 (BASF, 1969)
- LD50 (dermal, rabbit) > 3000 mg/kg bw (Huntsman, 1991)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 10 animals per dose, 7 days post-exposure observation
- Principles of method if other than guideline:
- BASF-test, see details in remarks on material and methods.
- GLP compliance:
- no
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Aminodiglykol, 2-(2 Hydroxyaethoxy-)aethylamin
- Physical state: liquid
- Analytical purity: > 99 % - Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 186 - 280 g (mean); female: 166 - 218 g (mean) - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 %, 20 % and 30 %. - Doses:
- 200, 1600, 2000, 2500, 3200, 4000, 5000, 6400 µl/kg bw = 212, 1696, 2120, 2650, 3392, 4240, 5300, 6784 mg/kg bw (conversation is based on the density of 1.06 g/cm3).
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 400 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 700 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 000 mg/kg bw
- Mortality:
- See details in remarks on results.
- Clinical signs:
- other: Staggering, abdomial position, apathy, irregular respiration, shallow flanks, closed eyes, ruffled fur.
- Gross pathology:
- 2120 - 6784 mg/kg bw: gastrorrhagia, sagged gastrointestinal tract, serous smeared snouts.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- oral LD50 ca. 3400 mg/kg (male/female)
- Executive summary:
In a study comparable to OECD guideline 401, the LD50 for oral acute toxicity in rats was calculated as ca. 3400 mg/kg body weight. Doses of 212, 1696, 2120, 2650, 3392, 4240, 5300, and 6784 mg/kg bw of an aqueous solution were applied by gavage followed by a post dose observation period of 7 days. Main clinical signs observed were staggering, apathy, irregular respiration, shallow flanks, abdomial position, closed eyes, ruffled fur. At necropsy, gastrorrhagia, sagged gastrointestinal tract and serous smeared snouts were observed.
Reference
Mortality
Dose (mg/kg bw) | Conc. (%) | Gender | 1 h | 24 h | 48 h | 8 days | |||||||||
6784 | 30 | male | 0/10 | 10/10 | 10/10 | 10/10 | |||||||||
6784 | 30 | female | 0/10 | 10/10 | 10/10 | 10/10 | |||||||||
5300 | 30 | male | 0/10 | 0/10 | 8/10 | 8/10 | |||||||||
4240 | 30 | male | 0/10 | 0/10 | 8/10 | 8/10 | |||||||||
3392 | 30 | male | 0/10 | 3/10 | 3/10 | 3/10 | |||||||||
3392 | 30 | female | 0/10 | 8/10 | 8/10 | 8/10 | |||||||||
2650 | 20 | female | 0/10 | 0/10 | 3/10 | 3/10 | |||||||||
2120 | 20 | female | 0/10 | 0/10 | 1/10 | 1/10 | |||||||||
1696 | 20 | male | 0/10 | 0/10 | 0/10 | 0/10 | |||||||||
1696 | 20 | female | 0/10 | 0/10 | 0/10 | 0/10 | |||||||||
212 | 2 | male | 0/10 | 0/10 | 0/10 | 0/10 | |||||||||
212 | 2 | female | 0/10 | 0/10 | 0/10 | 0/10 |
The test substance caused systemic toxicity (including mortality) in a dose dependent manner.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 400 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Mar 1969 - 19 Mar 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Inhalation-Risk-Test: BASF-test, see details in remarks on material and methods
- GLP compliance:
- no
- Test type:
- standard acute method
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Aminodiglykol, 2-(2-Hydroxyaethoxy-)aethylamin
- Physical state: liquid
- Analytical purity: > 99 % - Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 157 g (mean) - Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- In the raw data no substance loss but an increase in substance weight was recorded.
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of exposure and daily thereafter
- Frequency of weighing: day 0 and day 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 8.7 mg/m³ air (nominal)
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality occured within 8h; calculation based on the saturated vapor concentration
- Mortality:
- No mortality occured.
- Clinical signs:
- other: No symptoms observed.
- Body weight:
- The animals gained weight.
- Gross pathology:
- 2x bronchitis
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LC50 > 8.7 mg/m3
- Executive summary:
The inhalation of a saturated vapor-air mixture for 8 hours caused no mortality in the inhalation risk test. No clinical signs or indications at necropsy were observed.
Reference
The inhalation of a highly saturated vapour-air mixture for 8 h caused no mortality.
Calculation of the saturated vapor concenration is basd on the vapor pressure at 25°C = 0.002 hPa and the molecular weight = 105.14 g/mol which equals a sat. vapor conc. = 0.0087 mg/L = 8.7 mg/m³.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- > 8.7 mg/m³ air
- Physical form:
- inhalation: vapour
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 12 May 1981
- Deviations:
- yes
- Remarks:
- purity not reported
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Federal Register, Vol. 50 188
- Version / remarks:
- 27 September 1985
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 6398-21-1
- Physical state: clear, colorless liquid
- Analytical purity: responsibility of the Sponsor
- Lot/batch No.: 90-013
- Stability under test conditions: no apparent change in the physical characteristics of the test article during administration
- Storage condition of test material: no data
- Other: gravity: 1.06g/ml; pH=12 (litmus paper) - Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hare-Marland, Hewitt, New Jersey
- Age at study initiation: young adult
- Weight at study initiation: 2.119-2.764 kg
- Housing:Rabbits were housed individually in cages sized in accordance with the "Guide for the Care and Use of Laboratory Animals" of the Institute of Laboratory Animal Resources, National Research Council
- Diet (e.g. ad libitum): Purina Rabbit Ration H.F., ad libitum
- Water (e.g. ad libitum): fresh tap water, ad libitum
- Acclimation period: min. 5d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C±3°C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12h dark/12h light - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal area of trunk (clipped free of fur)
- Type of wrap if used: rubber dam and an elastic bandage
REMOVAL OF TEST SUBSTANCE: no data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3000 mg/kg
- Constant volume or concentration used: YES - Duration of exposure:
- 24h
- Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation daily through 14d, body weight recorded at d0, d7 and d14
- Necropsy of survivors performed: YES
- Other examinations performed: clinical signs, body weight - Statistics:
- Not applicable.
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 3 000 mg/kg bw
- Mortality:
- No mortality observed during study.
- Clinical signs:
- other: Days 1 and 2: 10/10 animals:decreased activity, abnormal stance& gait. Days 3 up to 14 no signs in all observed animals. Day 1: 1/10 animal:diarrhea. Days 3 up to 14 no signs in all observed animals. Day 2: 10/10 animals poor grooming. Days 3 up to 14 no
- Gross pathology:
- Terminal necropsy of the animals revealed severe irritation and/or yellow discoloration of the underlying muscle tissue at the application site, necrotic or discolored yellow fascia at the application site, mottled lungs and pale kidneys.
- Other findings:
- no other data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 3000mg/kg.
- Executive summary:
In a Limit Test, one group of 10 rabbits (5 males and 5 females) was dermally administered the test article at 3000 mg/kg. Clinical signs observed during the study included decreased activity, abnormal stance, abnormal gait, diarrhea, poor groo of fur surrounding the application site were observed. Necrosis and sloughing of the skin at application site, bilateral alopecia and a clear exudate from necrotic areas were also observed during the study. Terminal necropsy of the animals revealed severe irritation and/or yellow discoloration of the underlying muscle tissue at the application site, necrotic or discolored yellow fascia at the application site, mottled lungs and pale kidneys. Based on the observation made in the Acute Exposure Dermal Toxicity Study in rabbits, the estimated acute dermal LD50 was determined to be greater than 3000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 3 000 mg/kg bw
Additional information
Oral:
In a study which was in large parts equivalent to methods described in OECD guideline 401, the LD50 for oral acute toxicity in rats was calculated as ca. 3400 mg/kg body weight (BASF, 1969). Doses of 212, 1696, 2120, 2650, 3392, 4240, 5300, and 6784 mg/kg bw of an aqueous solution were applied by gavage followed by a post dose observation period of 7 days. Main clinical signs observed were staggering, apathy, irregular respiration, shallow flanks, abdomial position, closed eyes, ruffled fur. At necropsy, gastrorrhagia, sagged gastrointestinal tract and serous smeared snouts were observed. In two supporting studies with only limited data provided, the test substance caused likewise low toxicity after a single ingestion (LD50 = 2558 mg/kg bw; Huntsman 1991, LD50=5660 mg/kg bw; Smyth et al., 1951).
Inhalation:
The inhalation of a saturated vapor-air mixture for 8 hours caused no mortality in two inhalation risk tests. No clinical signs or indications at necropsy were observed (BASF, 1969; Smyth et al., 1951).
Dermal:
In the Key study an LD50 > 3000 mg/kg bw was reported (Huntsman, 1991). In the available limit-test as secondary source the acute dermal toxicity of 2-(2-aminoethoxy)ethanol was evaluated in rats according to OECD guideline 402 and in compliance with GLP. No mortalities were observed at the highest test dose level of 3000 mg/kg bw. Observations noted on live animals included decreased activity, poor grooming, diarrhoea, abnormal gait and stance and dyspnoea. A clear mucous anal discharge and a yellow discolouration of fur, with necrosis and skin sloughing surrounding the application site were observed. Terminal necropsy of animals revealed severe irritation and/or yellow discolouration of the underlying muscle tissue at the application site and also necrotic or discoloured fascia. Mottled lungs and pale kidneys were observed.
A dermal LD50 value of 1190 µl/kg bw, equivalent to 1260 mg/kg bw was published in a study for rabbits, with no further details provided (Smyth et al., 1966).
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result, the substance is not considered to be classified for acute oral or dermal toxicity under Regulation (EC) No. 1272/2008, as amended for the fourteenth time in Regulation (EC) No. 2020/217.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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