Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-290-6 | CAS number: 1319-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- August-December 2003
- Reliability:
- 1 (reliable without restriction)
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- There was one deviation from the study protocol which was concerned with the relative humidity (section 6.2 Husbandry). On some days of the study the relative humidity was higher than 70%.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Trilead dioxide phosphonate
- EC Number:
- 235-252-2
- EC Name:
- Trilead dioxide phosphonate
- Cas Number:
- 12141-20-7
- Details on test material:
- - Name of test material (as cited in study report): ALLSTAB LP 3139 dibasic lead phosphite
- Molecular formula (if other than submission substance): 2PBO x PbHPO3 x 0,5 H2O
- Physical state: fine white powder
- Analytical purity: 99.3%
- Composition of test material, percentage of components: 82.7% Pb; 0.2% water;
- Lot/batch No.: 210510067
- Expiration date of the lot/batch: >24 months after shipping
- Storage condition of test material: At room temperature. min. 24 months (after shipment), when stored in sealed containers at temperatures below 40 degrees centigrade.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann
- Weight at study initiation: 2.74, 2.75 and 3.26 kg.
- Housing: The rabbits were housed individually in a battery of cages with a cage size of 100 x 45 x 40 cm (L x B x H), equipped with a paper disposal system.
- Diet (e.g. ad libitum): Teklad Global Rabbit Diet ad libitum
- Water (e.g. ad libitum): Tap water as used for human consumption was continuously available ad libitum.
- Acclimation period: The animals were acclimatised to laboratory conditions for more than 5 days. Animals have been housed at the testing facility for 20 days or several months.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 degrees centigrade
- Humidity (%): 44-72%
- Air changes (per hr): 16 times/h and filtered adequately
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light with light on at 7:00 AM
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: The skin of the back of all animals was clipped 24 h before treatment and examined for potential lesions.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The test article was applied to the right side of the back and the untreated left side served as the control
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Skin reactions were assessed 1, 24, 48 and 72 hours after the end of the exposure.
- Number of animals:
- Three animals
- Details on study design:
- TEST SITE
- Area of exposure: Right side of the back. The untreated left side served as a control.
- Type of wrap if used: The test article was applied to a gauze patch and then applied to the skin
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Grading of skin reaction as stipulated by OECD 404
- Basis:
- mean
- Time point:
- other: 1, 24, 48, and 72 hours afer the time of exposure
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not relevant
- Irritant / corrosive response data:
- Very slight signs of erythema were seen 1 hour after patch removal in all three animals. Thereafter, no signs of erythma or oedema were observed. The mean grades at 24, 48 and 72 hours after the end of exposure were "0" in each animal.
- Other effects:
- No toxic effects with respect to the general condition were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: OECD 404
- Conclusions:
- The test article was classified on the basis of the mean values of skin reactions 24, 48 and 72 hours after the end of the 4-hour exposure according to the criteria specified by the EEC Directive 2001/59/EEC of 6 August 2001 and the Gefahrstoffverordnung (GefStoffV) of 15 November 1999 (BGB1. I, p. 2233). When applied to the skin, the test article "ALLSTAB LP 3139 dibasic lead phosphite" is classified as "non-irritant".
- Executive summary:
- The potential toxicity of "ALLSTAB LP 3139 dibasic lead phosphite" was
assessed in an acute dermal irritation/corrosion test on three albino
rabbits. In each animal, 0.5 g of the solid test article was applied on
the right side of the dorsal clipped region, the untreated left side
served as the control. Exposure duration was 4 hours. Both sides were
examined at 1, 24, 48 and 72 hours after the end of exposure. The
following results were obtained: -There were no skin irritating findings
with the exception of very slight erythema observed 1 hour after patch
removal in all three animals. -No general toxic effects were seen. -The
mean grades at 24, 48 and 72 hours after the end of exposure were "0" in
each animal. The test Article was classified on the basis of the mean
values of skin reactions 24, 48 and 72 hours after the end of the 4-hour
exposure according to the criteria specified by the EEC Directive
2001/59/EEC of 6 August 2001 and the Gefahrstoffverordnung (GefStoffV) of
15 November 1999 (BGB1. I, p. 2233). When applied to the skin, the test
article "ALLSTAB LP 3139 dibasic lead phosphite" is classified as
"non-irritant".
These results can be assigned to lead titanium trioxide since a read across based on a grouping of substances (Pb substances) is applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)