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Diss Factsheets
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EC number: 247-987-6 | CAS number: 26762-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited details on study design (exposure time, application type, scoring system), study in patients with known reactions to turpentine oil
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Menthane, monohydroperoxy derivative
- EC Number:
- 247-987-6
- EC Name:
- Menthane, monohydroperoxy derivative
- Cas Number:
- 26762-92-5
- Molecular formula:
- C10H20O2
- IUPAC Name:
- menthane, monohydroperoxy derivative
- Reference substance name:
- p-menthane hydroperoxide
- IUPAC Name:
- p-menthane hydroperoxide
- Details on test material:
- commercial sample which is a mixture of p-menthane-1-hydroperoxide and p-menthane-8-hydroperoxide
Constituent 1
Constituent 2
Method
- Type of population:
- other: patients with known turpentine oil allergy
- Ethical approval:
- confirmed, but no further information available
- Subjects:
- 11 volunteers 27-64 year
8 males, 3 females - Clinical history:
- no data except on turpentine oil allegy
- Controls:
- controls were not included in the experiment, but were stated to have been included to assess the irritant concentration of 1% test susbtance
- Route of administration:
- dermal
- Details on study design:
- Subjects were exposed to 0.1% and 0.4% of the test substance in parafin oil. 48 hours after exposure skin reactions were measured.
Results and discussion
- Results of examinations:
- 0.4% challenge
- Number of subjects with positive reactions: 1 (+ 2 marginally reactions)
- Number of subjects with negative reactions: 8
0.1% challenge
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 11
Applicant's summary and conclusion
- Conclusions:
- very weak sensitizer under the conditions of the test
- Executive summary:
Eleven subjects with known allegic reaction to turpentene oil were challenged with 0.1% and 0.4% test substance. With 0.4% very slight effects were seen. A challenge with 0.1% did not induce any effects. The test substance is considered a very weak sensitizer under the conditions of the test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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