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Diss Factsheets
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EC number: 629-705-7 | CAS number: 1228186-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.023 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.007 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.002 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 7.1 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 55 mg/kg sediment dw
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 11 mg/kg sediment dw
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 7.3 mg/kg soil dw
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
PNECs for Benzyl were based on (i) new generated data and (ii) existing data for analogous substance. Read-across from N-C16-C18(even numbered)-alkyl-N,N-dimethyl-C16-C18(even numbered)-alkyl-1-aminium chloride (DODMAC/DHTDMAC) is proposed for covering missing endpoints. This read-across is supported by the similarity between the structures (with the benzyl ring exception) and the comparison of the expected sensitive endpoints (acute ecotox data) demonstrating the similarity of the ecotoxicological profiles. The IUCLID includes the assumptions made and for the read-across, existing European Risk Assessment was used as core-document
Conclusion on classification
Dangerous substance directive:
N-benzyl-N-C16-18 (even numbered) -alkyl-N-methyl-C16-18 (even numbered) -alkyl-1-aminium chloride is considered as very toxic for the aquatic compartment based on the generated aquatic toxicity package with an EC50-48h for invertebrates of 0.66 mg/L. The lowest NOEC was obtainded for fish and was 0.23 mg/L (based on a read-across with Quaternary ammonium compounds, di-C16 -18 (even numbered) - alkyldimethyl, chlorides).
N-benzyl-N-C16-18 (even numbered) -alkyl-N-methyl-C16-18 (even numbered) -alkyl-1-aminium chloride is considered to be non bioaccumulative but as the substance is considered not to be readily biodegradable, a chronic class has to be assigned.
Therefore based on the a.m results N-benzyl-N-C16-18 (even numbered) -alkyl-N-methyl-C16-18 (even numbered) -alkyl-1-aminium chloride is classified as follows:
N-R50/53
Classification Labeling & Packaging:
N-benzyl-N-C16-18 (even numbered) -alkyl-N-methyl-C16-18 (even numbered) -alkyl-1-aminium chloride is considered as very toxic for the aquatic compartment based on the generated aquatic toxicity package with an EC50-48h for invertebrates of 0.66 mg/L.
N-benzyl-N-C16-18 (even numbered) -alkyl-N-methyl-C16-18 (even numbered) -alkyl-1-aminium chloride is also considered as persistent in the environment, based on the results of a ready biodegradation test and the high log Kow value.
Therefore based on the a.m results N-benzyl-N-C16-18 (even numbered) -alkyl-N-methyl-C16-18 (even numbered) -alkyl-1-aminium chloride is classified as follows:
Aquatic chronic category 1 – H410: very toxic to aquatic life with long lasting effects.
Acute M-factor = 1
Chronic M-factor = 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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