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Diss Factsheets
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EC number: 247-987-6 | CAS number: 26762-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The LD50 value of the test substance tested in rats is > 2000 mg/kg bw. This is confirmed by tests with the structural analogues cumene hydroperoxide (Dow 1975) and diisopropyl benzene hydroperoxide (Hüls 1984). No additional acute toxicity studies were performed with the test substance due to its corrosive properties. A dermal toxicity study in rabbits with the structural analogue cumene hydroperoxide is available, but is considered unsuitable for evaluation in view of the low quality.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12/04 to 11/05 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study under GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Hsd/Win:WU
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, 33167 Borchen
- Age at study initiation: young adults
- Weight at study initiation: Males 148-184 g; Females 131-144
- Fasting period before study: 16 hours before application until 3 hours after application
- Housing: 5 animals/macrolon III cage
- Diet: Ssniff standard laboratory rat feed ad libitum
- Water: ad libitum
- Acclimation period: > 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 30-70%
- Air changes (per hr):15/hr
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 12-04-1994 To: 11-05-1994 - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2.2 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
clinical signs at 0.5, 1, 2 ,3, 4, 5, 6 hours post dosing and daily thereafter for 14 days
body weight on day 0, 7 and 14
- Necropsy of survivors performed: yes, macroscopic examination - Statistics:
- not applicable
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: Males: abnormal gait, hunched posture ,flat body posture, ventro-lateral recumbency, piloerection, ataxia, diarrhea hypothermia in all males until day 4 abnormal gait, hunched posture and piloerection persisting in one male until day 14 Females: abnorma
- Gross pathology:
- adhesions of abdominal organs to the peritoneum and cartilage like thickening of peritoneum
gastrointestrinal tract adhesions - Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
Rats received the test substance at 2000 mg/kg bw by oral gavage. No mortality was observed. The oral LD50 is > 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- guideline study under GLP
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Quality of whole database:
- only 2-4 animals tested per dose. According to the poor study quality, the study does not allow conclusions for the test substance.
Additional information
Data requirements on all acute toxicity endpoints are fulfilled. Due to the corrosiveness of the test substance no additional studies need to be performed (Column 2 of Annex VIII).
Justification for selection of acute toxicity – oral endpoint
guideline study under GLP
Justification for selection of acute toxicity – dermal endpoint
Based on a study with the structural analogue cumene hydroperoxide. As the test substance is corrosive, no additional testing needs to be performed according to column 2 of Annex VIII
Justification for classification or non-classification
The test substance does not need to be classified for acute toxicity. No classification is necessary. The dermal study with the analogue is considered not adequate. As the substance is corrosive no additional animal data will be generated (waiver based on column 2 of Annex VIII).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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