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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 214-604-9 | CAS number: 1163-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
The comercial DecaBDE product did not induce maternal or fetal toxicity at doses up to 1000 mg/kg/d in rats administered the material in corn oil from GD0 -19 (NOEL = 1000 mg/kg bw/d). The commercial DecaBDE product did not induce developmental neurotoxicity in rats exposed in utero and via lactation through post-natal day 21 (NOAEL = 1000 mg/kg bw/d). No effects on the reproductive system were observed in male or female rats and mice when the commercial DecaBDE product was administered for a lifetime (e.g. two years) at doses up to 5% of the diet. Similarly, no effects on the reproductive system were observed in male or female rats and mice at doses up to 5% of the diet for 90 d. A one-generation reproduction study in rats using the former commercial product FR 300BA (~77% BDE 209, ~22% NonaBDEs and 0.8% OctaBDEs) indicated no effects on fertility at doses up to 100 mg/kg bw/d administered in the diet prior to and during mating, gestation, and development.
Short description of key information:
90 D, 13 Wk, 2 year studies in rats and mice. Rat prenatal developmental, Rat developmental neurotoxicity.
Effects on developmental toxicity
Description of key information
Prenatal developmental and developmental neurotoxicity studies.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
The rat oral NOEL from a guideline- and GLP compliant prenatal developmental study was 1000 mg/kg bw/d, the highest dose tested, administered from gestation day 0 - 19. The rat oral NOAEL from a guideline- and GLP-compliant developmental neurotoxicity study was 1000 mg/kg bw/d administered to maternal animals from gestation day 6 through lactation day 21. See Hardy et al. 2009 (Critical Reviews in Toxicology 39(S2):1 -44) additional discussion.
Justification for classification or non-classification
DecaBDE is not a reproductive or developmental toxicant at doses up to, and exceeding, 1000 mg/kg bw/d. See Hardy et al. (Critical Reviews in Toxicology 39 (S3):1 -44) for a discussion.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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