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EC number: 443-510-2 | CAS number: 738587-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study Experimental phase 2002-09-20 to 2003-02-05. Report Date 2003-04-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets the criteria for classification as Reliable without restriction according to Klimisch et al (1997)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 443-510-2
- EC Name:
- -
- Cas Number:
- 738587-10-5
- Molecular formula:
- C26H14N10Ni2O18S4 as free acid
- IUPAC Name:
- dinickel(2+) sodium 3-carboxy-5-[(1E)-2-(7-oxido-2,6-disulfonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide 3-carboxy-5-[(1E)-2-(7-oxido-2-sulfo-6-sulfonatonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Buffers:
- - pH 4.0 Buffer Solution
164ml of 0.2M acetic acid solution added to 36ml of 0.2M sodium acetate solution and diluted to 1 litre with distilled/deionised water. Measured pH = 4.01
- pH 7.0 Buffer solution
296ml of 0.1M sodium hydroxide solution added to 500ml of 0.1M monopotassium phosphate solution and diluted to 1 litre with distilled/deionised water. Measured pH = 7.05
- pH 9.0 Solution
0.1M sodium hydroxide solution, pH adjusted to 9 with 0.1M hydrochloric acid. Measured pH = 9.10
All buffer solutions were degassed with helium before use. - Details on test conditions:
- Preparation of Test Solutions
The tests were prepared in duplicate in each buffer solution at around 0.5 g/L and placed in an oven at 50 +/-1 degree C. Analysis of the tests (by HPLC) was carried out initially and then over several days.
Duration of testopen allclose all
- Duration:
- 7 d
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- 5.13 g/L
- Duration:
- 7 d
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- 4.9 g/L
- Duration:
- 7 d
- pH:
- 9
- Temp.:
- 50
- Initial conc. measured:
- 5.36 g/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Preliminary study:
- Less than 10% hydrolysis had occured at pH 4, 7 and 9 after five days storage at 50 +/-1 degree C therefore no further testing was carried out.
- Transformation products:
- no
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 98.1
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 98.5
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 100.2
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 103.8
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 7 d
- % Recovery:
- 101.1
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 102.1
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Details on results:
- Less than 10% hydrolysis had occurred in the preliminary study at all three pH's after 5 days storage at 50°C ± 1 deg C therefore, no further testing was carried out.
Applicant's summary and conclusion
- Conclusions:
- In conclusion less than 10% hydrolysis had occurred in the preliminary study at pH 4, 7 and 9 after 5 days storage at 50°C ± 1 deg C.
- Executive summary:
Introduction
This study was undertaken to assess the hydrolysis of the test substance at different pH values.
Results & Conclusions
After 5 days <10% hydrolysis occured at pH's 4, 7 and 9 therefore, no further work was carried out.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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