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Diss Factsheets
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EC number: 206-200-6 | CAS number: 307-35-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The experimental study is referred to Potassium PFOS (Perfluorooctane sulfonic acid). The substance RM90 is a salt of PFOS too.
Data source
Reference
- Reference Type:
- publication
- Title:
- ENVIRONMENTAL AND HEALTH ASSESSMENT OF PERFLUOROOCTANE SULFONIC ACID AND ITS SALTS
- Author:
- 3M
- Bibliographic source:
- Various sources listed in the assessment report.
- Report date:
- 2003
Materials and methods
Test guideline
- Guideline:
- other: not known
- Principles of method if other than guideline:
- Method not available in the pubblication.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium PFOS
- IUPAC Name:
- Potassium PFOS
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
The F1 rats in all these groups developed normally as measured by an array of developmental milestones, including neurobehavioral performance. Effects on reproduction, lactation and on postnatal viability of the F2 pups were modest and transient.
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 0.1 mg/kg bw/day
- Based on:
- not specified
- Dose descriptor:
- LOAEL
- Effect level:
- 0.4 mg/kg bw/day
- Based on:
- not specified
- Basis for effect level:
- other: Body weight gain reduction
- Dose descriptor:
- NOAEL
- Effect level:
- 1.6 mg/kg bw/day
- Based on:
- not specified
- Dose descriptor:
- LOAEL
- Effect level:
- 3.2 mg/kg bw/day
- Based on:
- not specified
- Basis for effect level:
- other: Implantation and litter size reduction.
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 0.4 mg/kg bw/day
- Based on:
- not specified
- Basis for effect level:
- other: Neonatal mortality increase and body weight reduction. Effects on reproductive parameters.
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- NOAEL
- Generation:
- F2
- Effect level:
- 0.4 mg/kg bw/day
- Based on:
- not specified
- Basis for effect level:
- other: Effects on all measured parameters.
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Maternal body weight changes are observed in the pre-natal teratology studies and the two generation studies. Results of the two-generation study indicate that fertility and reproductive performance are not impared at doses that cause adverse body weight effects on males and females. However, the mortality seen in the perinatal period of life has no parallel in the prenatal studies. While modest increase in resorptions were seen in the two-generation studies, pup development until the time of birth was fairly normal. The incidence of pup mortality was severe at the higher doses
on day of birth and in the immediate perinatal period. The study design did not permit insight as to the factor that contributed to this effect.
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