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Diss Factsheets
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EC number: 605-399-0 | CAS number: 165252-70-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21/05/1996 - 09/12/1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (1981)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Version / remarks:
- (1982)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: JMAFF 59 NohSan No. 4200 (1985)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine
- EC Number:
- 605-399-0
- Cas Number:
- 165252-70-0
- Molecular formula:
- C7H14N4O3
- IUPAC Name:
- (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine
- Test material form:
- solid: particulate/powder
- Remarks:
- powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Crl:CD1[ICR]BR (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Age at study initiation:
- Range finding study: 4 to 8 weeks old
- Definitive study: 4 to 10 weeks old
Weight at study initiation:
- Range finding study: 24.9 to 27.8 g
- Definitive study: 23.0 to 29.6 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration of vehicle: 0.5 % CMC in distilled water
- Amount of vehicle (if gavage): 20 mL/kg
- Justification for choice of vehicle: no data - Doses:
- Range finding study: 500, 1000, 3000, 5000 mg/kg bw
Definitive study: 1000, 2000, 3000 mg/kg bw - No. of animals per sex per dose:
- Range finding study: 1 mouse per sex per dose
Definitive study: 5 mice per sex per dose - Control animals:
- no
- Details on study design:
- - Duration of test/exposure period: 14 days
- Rational for dose level selection: The definitive study dose levels were selected based on the results from the range finding study
- Post exposure observation period: 14 days - Statistics:
- The LD50 and 95% confidence limits for the individual sexes and the sexes combined were determined by a modified Behrens-Reed-Muench cumulant method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 450 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 801 - < 3 331
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 275 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 537 - < 3 369
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 371 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 884 - < 2 983
- Remarks on result:
- other: male and female combined
- Mortality:
- - In the range-finding study, both animals treated at 5000mg/kg and the male treated at 3000mg/kg died on the day of treatment. All other animals survived the observation period.
- In the main study, deaths occurred at dose levels of ≥2000mg/kg but not at 1000mg/kg (Table 1). All deaths in the main study occurred on the day of treatment. - Clinical signs:
- other: Transient clinical signs of toxicity, on the day of treatment only, were apparent at dose levels of ≥2000mg/kg and included hypoactivity, staggering gait, dyspnea, tonic convulsions and tremors.
- Gross pathology:
- Necropsy and post mortem examination revealed no gross lesions in either decedents or survivors killed at the end of the observation period.
Any other information on results incl. tables
Table 1: Mortality and time of death
Dose level |
Number dying / number tested |
|||
(mg/kg) |
Dose range-finding study |
Main study |
||
|
Male |
Female |
Male |
Female |
500 |
0 / 1 |
0 / 1 |
- |
- |
1000 |
0 / 1 |
0 / 1 |
0 / 5 |
0 / 5 |
2000 |
- |
- |
1a/ 5 |
2a/ 5 |
3000 |
1a/ 1 |
0 / 1 |
4a/ 5 |
4a/ 5 |
5000 |
1a/ 1 |
1a/ 1 |
- |
- |
adied on the day of treatment;
- not tested
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Conclusions:
- The acute oral median lethal dose (LD50) and 95% confidence limits were calculated to be 2450 mg/kg and 1801-3331 mg/kg for males, 2275 mg/kg and 1537-3369 mg/kg for females and 2371 mg/kg and 1884-2983 mg/kg for the sexes combined. Therefore, dinotefuran does not require classification according to Reg. (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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